Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Sumit Mukherjee; Milana Frenkel-Morgenstern

doi:10.1016/j.tig.2021.08.015

Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Sumit Mukherjee
, Milana Frenkel-Morgenstern

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

Original language	English
Pages (from-to)	4-7
Number of pages	4
Journal	Trends in Genetics
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.tig.2021.08.015
State	Published - 1 Jan 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer evolution
chimeric RNA
gene fusion
phenotypic plasticity

ASJC Scopus subject areas

Genetics

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10.1016/j.tig.2021.08.015

Cite this

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title = "Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells",

abstract = "Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.",

keywords = "cancer evolution, chimeric RNA, gene fusion, phenotypic plasticity",

author = "Sumit Mukherjee and Milana Frenkel-Morgenstern",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = jan,

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doi = "10.1016/j.tig.2021.08.015",

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T1 - Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

AU - Mukherjee, Sumit

AU - Frenkel-Morgenstern, Milana

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

AB - Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

KW - cancer evolution

KW - chimeric RNA

KW - gene fusion

KW - phenotypic plasticity

UR - https://www.scopus.com/pages/publications/85115978426

U2 - 10.1016/j.tig.2021.08.015

DO - 10.1016/j.tig.2021.08.015

M3 - Short survey

C2 - 34579972

AN - SCOPUS:85115978426

SN - 0168-9525

VL - 38

SP - 4

EP - 7

JO - Trends in Genetics

JF - Trends in Genetics

IS - 1

ER -

Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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