Evolutionary mechanism for biosynthesis of diverse molecules

Akhileshwar Kumar Srivastava, Arpana Yadava, Divya Singh

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Evolution alters in gene sequence and/or genetic construction that change in mechanisms for biosynthesis of secondary metabolites. Plants synthesize a different array of lineage-specific specialized (secondary) metabolites for the fitness of the plants as defense against herbivores and microbes and also as signal factors to entice pollinators and fruit dispersers. The evolution of secondary metabolites also depends on alteration in the enzymatic manipulation of primary precursors. Plant metabolites play a vital role in plant adaptation, in human nutrition and medicine. The diversification of plant metabolic enzymes and primary metabolism evolves potential compounds for cellular homeostasis in selection pressure that is usually supposed to be conserved over the plant kingdom. The enormous changes in chemical diversity of secondary metabolites are occurred during evolution, which play vital role in treatment of severe diseases including cancer. This chapter explains the evolution of secondary metabolites through various evolutionary events occurring in plant system.

Original languageEnglish
Title of host publicationEvolutionary Diversity as a Source for Anticancer Molecules
PublisherElsevier Science Ltd.
Pages1-27
Number of pages27
ISBN (Electronic)9780128217108
ISBN (Print)9780128216989
DOIs
StatePublished - 1 Jan 2020
Externally publishedYes

Keywords

  • Drug discovery
  • Evolution
  • Gene cluster
  • Metabolic pathways

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology

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