TY - JOUR
T1 - Evolutionary perspective on the hematopoietic system through a colonial chordate
T2 - allogeneic immunity and hematopoiesis
AU - Rosental, Benyamin
AU - Raveh, Tal
AU - Voskoboynik, Ayelet
AU - Weissman, Irving L.
N1 - Funding Information:
We would like to thank Mark Kowarsky, Stephen R. Quake, Jun Seita, Katherine J. Ishizuka, Karla J. Palmeri, D. Nathaniel Clarke, Chris Lowe, Lucia Manni, Chiara Anselmi, and Ronnie Voskoboynik for meaningful discussions. This study was supported by N.I.H. grants R56AI089968, R01AG037968 and RO1GM100315 (to I.L.W. S.R.Q. and A.V.), the Chan Zuckerberg investigator program (to I.L.W and A.V), the Virginia and D.K. Ludwig Fund for Cancer Research, a grant from the Siebel Stem Cell Institute and a Stinehart-Reed grant (to I.L.W.). B.R. was supported by ISF grants 1416/19, and HFSP Research Grant, RGY0085/2019.
Funding Information:
We would like to thank Mark Kowarsky, Stephen R. Quake, Jun Seita, Katherine J. Ishizuka, Karla J. Palmeri, D. Nathaniel Clarke, Chris Lowe, Lucia Manni, Chiara Anselmi, and Ronnie Voskoboynik for meaningful discussions. This study was supported by N.I.H. grants R56AI089968 , R01AG037968 and RO1GM100315 (to I.L.W., S.R.Q., and A.V.), the Chan Zuckerberg investigator program (to I.L.W and A.V), the Virginia and D.K. Ludwig Fund for Cancer Research , a grant from the Siebel Stem Cell Institute and a Stinehart-Reed grant (to I.L.W.). B.R. was supported by ISF grants 1416/19 , and HFSP Research Grant, RGY0085/2019 .
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Evolution and selection have shaped diverse immune systems throughout phylogeny, the vast majority of which remain unexplored. Botryllus schlosseri is a colonial tunicate, a sister group to vertebrates, that develops as a chordate, then metamorphoses to an asexually reproductive invertebrate that every week makes the same body plan from budded stem cells. Genetically distinct B. schlosseri colonies can fuse to form a chimera, or reject each other based on allogeneic recognition. In chimeras, circulating germline and somatic stem cells participate in development; stem cells compete in all individuals in the fused colonies, with rejection preventing germline parasitism. Here we review the isolation and characterization of B. schlosseri hematopoietic stem cells (HSC) and their niches, and the role of the immune effector cells in allorecognition.
AB - Evolution and selection have shaped diverse immune systems throughout phylogeny, the vast majority of which remain unexplored. Botryllus schlosseri is a colonial tunicate, a sister group to vertebrates, that develops as a chordate, then metamorphoses to an asexually reproductive invertebrate that every week makes the same body plan from budded stem cells. Genetically distinct B. schlosseri colonies can fuse to form a chimera, or reject each other based on allogeneic recognition. In chimeras, circulating germline and somatic stem cells participate in development; stem cells compete in all individuals in the fused colonies, with rejection preventing germline parasitism. Here we review the isolation and characterization of B. schlosseri hematopoietic stem cells (HSC) and their niches, and the role of the immune effector cells in allorecognition.
UR - http://www.scopus.com/inward/record.url?scp=85077809661&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2019.12.006
DO - 10.1016/j.coi.2019.12.006
M3 - Review article
C2 - 31954962
AN - SCOPUS:85077809661
SN - 0952-7915
VL - 62
SP - 91
EP - 98
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -