Evolving trends in nonalcoholic fatty liver disease

Jorge Shmuel Delgado

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common etiologies of chronic liver disease worldwide. NALFD encompasses a continuum of histological findings ranging from steatosis alone, to nonalcoholic steatohepatitis (NASH) with steatosis, inflammation, hepatocyte ballooning, fibrosis and eventually liver cirrhosis. The pathogenesis of NAFLD might be related to a deregulated cross-talk between liver and visceral adipose tissue, originating an impairment of normal insulin signaling. A better comprehension of the immunologic and metabolic roles of adipose tissue in modulating inflammatory pathways will enhance our understanding of the molecular mechanisms leading to progression of fatty liver disease. These insights, moreover, will suggest new strategies to improve insulin sensitivity and reduce obesity-associated morbidities and mortality.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalEuropean Journal of Internal Medicine
Volume19
Issue number2
DOIs
StatePublished - 1 Mar 2008
Externally publishedYes

Keywords

  • Insulin resistance
  • Metabolic syndrome
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • Visceral adipose tissue

ASJC Scopus subject areas

  • Internal Medicine

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