Exaggerated fibrosis in patients with systemic sclerosis (scleroderma) following radiation therapy

M. Abu-Shakra, P. Lee

    Research output: Contribution to journalArticlepeer-review

    66 Scopus citations

    Abstract

    We describe 2 patients with systemic sclerosis (scleroderma) who developed severe localized skin thickening following radiation therapy for cancer. Radiation therapy may result in intense localized areas of fibrosis in patients with scleroderma. The fibrosis may extend beyond the irradiation portals and result in damage to underlying viscera. Radiotherapy may precipitate scleroderma or cause a generalized worsening of the underlying disease.

    Original languageEnglish
    Pages (from-to)1601-1603
    Number of pages3
    JournalJournal of Rheumatology
    Volume20
    Issue number9
    StatePublished - 1 Dec 1993

    Keywords

    • CANCER
    • RADIATION THERAPY
    • SCLERODERMA
    • SYSTEMIC SCLEROSIS

    ASJC Scopus subject areas

    • Rheumatology
    • Immunology and Allergy
    • Immunology

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