Exaggerated phosphaturic response to volume expansion in patients with essential hypertension

C. Chaimovitz, A. Spierer, H. Leibowitz, S. Tuma, O. S. Better

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Tubular handling of sodium in hypertensive patients was evaluated with urinary phosphate excretion used as a marker for proximal tubular reabsorptive capacity. 9 hypertensive patients and 9 normal control subjects were studied during sustained water diuresis and the i.v. infusion of isotonic sodium chloride solution to produce volume expansion. In the hypertensive patients there was exaggerated phosphaturia, natriuresis and enhanced distal delivery of sodium. Sodium reabsorption in the diluting segment was normal. The enhanced distal delivery and augmented phosphaturia suggest that a decreased reabsorption of sodium in the proximal tubule is the most likely explanation for the exaggerated natriuretic response to volume expansion in hypertensive patients.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalClinical Science
Issue number3
StatePublished - 1 Jan 1975
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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