TY - JOUR
T1 - Examining the Overlap Between ADHD and Autism Spectrum Disorder (ASD) Using Candidate Endophenotypes of ADHD
AU - Salunkhe, G.
AU - Weissbrodt, K.
AU - Feige, B.
AU - Saville, C. W.N.
AU - Berger, A.
AU - Dundon, N. M.
AU - Bender, S.
AU - Smyrnis, N.
AU - Beauducel, A.
AU - Biscaldi, M.
AU - Klein, C.
N1 - Publisher Copyright:
© The Author(s) 2018.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Objective: Recent discussions of aetiological overlap between ADHD and Autism Spectrum Disorder (ASD) require comparative studying of these disorders. Method: We examined performance of ASD patients with (ASD+) and without (ASD–) comorbid ADHD, ADHD patients, and controls for selected putative endophenotypes of ADHD: Intrasubject Variability (ISV) of reaction times, working memory (WM), inhibition, and temporal processing. Results: We found that patients with ADHD or ASD+, but not ASD–, had elevated ISV across the entire task battery and temporal processing deficits, and that none of the groups were impaired in WM or inhibition. High levels of ISV and generally poor performance in ASD+ patients were only partially due to additive effects of the pure disorders. Conclusion: Overall, we conclude that, within our limited but heterogeneous task battery, ISV and temporal processing deficits are most sensitive to ADHD symptomatology and that controlling for ADHD comorbidity is mandatory when assessing ISV in autism.
AB - Objective: Recent discussions of aetiological overlap between ADHD and Autism Spectrum Disorder (ASD) require comparative studying of these disorders. Method: We examined performance of ASD patients with (ASD+) and without (ASD–) comorbid ADHD, ADHD patients, and controls for selected putative endophenotypes of ADHD: Intrasubject Variability (ISV) of reaction times, working memory (WM), inhibition, and temporal processing. Results: We found that patients with ADHD or ASD+, but not ASD–, had elevated ISV across the entire task battery and temporal processing deficits, and that none of the groups were impaired in WM or inhibition. High levels of ISV and generally poor performance in ASD+ patients were only partially due to additive effects of the pure disorders. Conclusion: Overall, we conclude that, within our limited but heterogeneous task battery, ISV and temporal processing deficits are most sensitive to ADHD symptomatology and that controlling for ADHD comorbidity is mandatory when assessing ISV in autism.
KW - endophenotypes
KW - intrasubject variability
KW - response inhibition
KW - temporal reproduction
KW - working memory
UR - http://www.scopus.com/inward/record.url?scp=85048880339&partnerID=8YFLogxK
U2 - 10.1177/1087054718778114
DO - 10.1177/1087054718778114
M3 - Article
C2 - 29896994
AN - SCOPUS:85048880339
SN - 1087-0547
VL - 25
SP - 217
EP - 232
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 2
ER -