Examining the Temporal Association between Substance Abuse/Dependence and Mania in Older Adults

S Canham; C Kaufmann; C Ramsey; AP Spira; N O'Rourke

doi:10.1093/geront/gnt151

Abstract

Comorbid mania and substance abuse/dependence is an increasing
public health concern among older adults, though the temporal relationship between them is unclear. We studied 13,489 participants aged
≥50 years at Wave 1 (W1: 2001-2002) and Wave 2 (W2: 2004-2005)
of the National Epidemiologic Survey on Alcohol and Related Conditions. We examined whether lifetime mania at W1 predicted incident
alcohol or drug abuse/dependence by W2; and whether lifetime alcohol or drug abuse/dependence at W1 predicted incident manic episode
by W2. At W1, 276 adults had mania; at W2, 132 adults had an incident manic episode. Older adults with lifetime alcohol abuse/dependence at W1 had an elevated risk of incident manic episodes (adjusted
odds ratio=2.11, 95% confidence interval=1.19-3.75, p=0.011); there
was no association between lifetime mania at W1 and incident substance
abuse/dependence at W2. Because substance abuse complicates remission from mania, attention to older adults with substance abuse/dependence histories is needed.

Original language	English
Pages (from-to)	29-29
Number of pages	1
Journal	The Gerontologist
Volume	53
Issue number	S1
DOIs	https://doi.org/10.1093/geront/gnt151
State	Published - Nov 2013

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title = "Examining the Temporal Association between Substance Abuse/Dependence and Mania in Older Adults",

abstract = "Comorbid mania and substance abuse/dependence is an increasingpublic health concern among older adults, though the temporal relationship between them is unclear. We studied 13,489 participants aged≥50 years at Wave 1 (W1: 2001-2002) and Wave 2 (W2: 2004-2005)of the National Epidemiologic Survey on Alcohol and Related Conditions. We examined whether lifetime mania at W1 predicted incidentalcohol or drug abuse/dependence by W2; and whether lifetime alcohol or drug abuse/dependence at W1 predicted incident manic episodeby W2. At W1, 276 adults had mania; at W2, 132 adults had an incident manic episode. Older adults with lifetime alcohol abuse/dependence at W1 had an elevated risk of incident manic episodes (adjustedodds ratio=2.11, 95% confidence interval=1.19-3.75, p=0.011); therewas no association between lifetime mania at W1 and incident substanceabuse/dependence at W2. Because substance abuse complicates remission from mania, attention to older adults with substance abuse/dependence histories is needed.",

author = "S Canham and C Kaufmann and C Ramsey and AP Spira and N O'Rourke",

note = "66th Annual Scientific Meeting “Optimal Aging Through Research”",

year = "2013",

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doi = "10.1093/geront/gnt151",

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T1 - Examining the Temporal Association between Substance Abuse/Dependence and Mania in Older Adults

AU - Canham, S

AU - Kaufmann, C

AU - Ramsey, C

AU - Spira, AP

AU - O'Rourke, N

N1 - 66th Annual Scientific Meeting “Optimal Aging Through Research”

PY - 2013/11

Y1 - 2013/11

N2 - Comorbid mania and substance abuse/dependence is an increasingpublic health concern among older adults, though the temporal relationship between them is unclear. We studied 13,489 participants aged≥50 years at Wave 1 (W1: 2001-2002) and Wave 2 (W2: 2004-2005)of the National Epidemiologic Survey on Alcohol and Related Conditions. We examined whether lifetime mania at W1 predicted incidentalcohol or drug abuse/dependence by W2; and whether lifetime alcohol or drug abuse/dependence at W1 predicted incident manic episodeby W2. At W1, 276 adults had mania; at W2, 132 adults had an incident manic episode. Older adults with lifetime alcohol abuse/dependence at W1 had an elevated risk of incident manic episodes (adjustedodds ratio=2.11, 95% confidence interval=1.19-3.75, p=0.011); therewas no association between lifetime mania at W1 and incident substanceabuse/dependence at W2. Because substance abuse complicates remission from mania, attention to older adults with substance abuse/dependence histories is needed.

AB - Comorbid mania and substance abuse/dependence is an increasingpublic health concern among older adults, though the temporal relationship between them is unclear. We studied 13,489 participants aged≥50 years at Wave 1 (W1: 2001-2002) and Wave 2 (W2: 2004-2005)of the National Epidemiologic Survey on Alcohol and Related Conditions. We examined whether lifetime mania at W1 predicted incidentalcohol or drug abuse/dependence by W2; and whether lifetime alcohol or drug abuse/dependence at W1 predicted incident manic episodeby W2. At W1, 276 adults had mania; at W2, 132 adults had an incident manic episode. Older adults with lifetime alcohol abuse/dependence at W1 had an elevated risk of incident manic episodes (adjustedodds ratio=2.11, 95% confidence interval=1.19-3.75, p=0.011); therewas no association between lifetime mania at W1 and incident substanceabuse/dependence at W2. Because substance abuse complicates remission from mania, attention to older adults with substance abuse/dependence histories is needed.

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DO - 10.1093/geront/gnt151

M3 - Meeting Abstract

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VL - 53

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JO - The Gerontologist

JF - The Gerontologist

IS - S1

ER -

Examining the Temporal Association between Substance Abuse/Dependence and Mania in Older Adults

Abstract

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