TY - JOUR
T1 - Excitatory deep transcranial magnetic stimulation with H-coil over the right homologous Broca's region improves naming in chronic post-stroke aphasia
AU - Chieffo, Raffaella
AU - Ferrari, Federico
AU - Battista, Petronilla
AU - Houdayer, Elise
AU - Nuara, Arturo
AU - Alemanno, Federica
AU - Abutalebi, Jubin
AU - Zangen, Abraham
AU - Comi, Giancarlo
AU - Cappa, Stefano F.
AU - Leocani, Letizia
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Joint Italian-Israeli Laboratory San Raffaele-Weizmann (Italian Ministry of Foreign Affairs).
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Background. The role of the right hemisphere in poststroke aphasia recovery is still controversial and the effects of repetitive transcranial magnetic stimulation (rTMS) over the right homologous Broca's region have been seldom investigated. Objective. This study aimed to compare the effect of excitatory, inhibitory, and sham rTMS delivered with H-coil over the right inferior frontal gyrus in chronic aphasic patients. Methods. Five right-handed poststroke aphasic patients underwent a picture naming task before and immediately after each of 3 sessions of rTMS: excitatory (10 Hz), inhibitory (1 Hz), and sham rTMS, in random sequence and separated by at least 1 week. Results. Only the excitatory 10-Hz stimulation was associated with a significant improvement in naming performance (P =.043) and was significantly more effective than 1-Hz rTMS (P =.043). Conclusions. A single session of excitatory deep brain rTMS over the right inferior frontal gyrus with H-coil significantly improves naming in right-handed chronic poststroke aphasic patients. This result is in line with the hypothesis of a positive, rather than detrimental, role of the right hemisphere in chronic aphasia due to a left-hemispheric stroke.
AB - Background. The role of the right hemisphere in poststroke aphasia recovery is still controversial and the effects of repetitive transcranial magnetic stimulation (rTMS) over the right homologous Broca's region have been seldom investigated. Objective. This study aimed to compare the effect of excitatory, inhibitory, and sham rTMS delivered with H-coil over the right inferior frontal gyrus in chronic aphasic patients. Methods. Five right-handed poststroke aphasic patients underwent a picture naming task before and immediately after each of 3 sessions of rTMS: excitatory (10 Hz), inhibitory (1 Hz), and sham rTMS, in random sequence and separated by at least 1 week. Results. Only the excitatory 10-Hz stimulation was associated with a significant improvement in naming performance (P =.043) and was significantly more effective than 1-Hz rTMS (P =.043). Conclusions. A single session of excitatory deep brain rTMS over the right inferior frontal gyrus with H-coil significantly improves naming in right-handed chronic poststroke aphasic patients. This result is in line with the hypothesis of a positive, rather than detrimental, role of the right hemisphere in chronic aphasia due to a left-hemispheric stroke.
KW - H-coil
KW - aphasia
KW - rTMS
KW - stroke rehabilitation
KW - transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=84894156129&partnerID=8YFLogxK
U2 - 10.1177/1545968313508471
DO - 10.1177/1545968313508471
M3 - Article
C2 - 24243918
AN - SCOPUS:84894156129
SN - 1545-9683
VL - 28
SP - 291
EP - 298
JO - Neurorehabilitation and Neural Repair
JF - Neurorehabilitation and Neural Repair
IS - 3
ER -