Exercise-induced albuminuria is related to metabolic syndrome

Sharon Greenberg, Shani Shenhar-Tsarfaty, Ori Rogowski, Itzhak Shapira, David Zeltser, Talia Weinstein, Dror Lahav, Jaffa Vered, Oholi Tovia-Brodie, Yaron Arbel, Shlomo Berliner, Assi Milwidsky

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA and metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in a large sample of apparently healthy individuals with no baseline albuminuria. This was a cross-sectional study of 2,027 adults with no overt cardiovascular diseases who took part in a health survey program and had no baseline MA. Diagnosis of MS was based on harmonized criteria. All patients underwent an exercise test (Bruce protocol), and urinary albumin was measured before and after the examination. Urinary albuminto-creatinine ratio (ACR) values before and after exercise were 0.40 (0.21–0.89) and 1.06 (0.43–2.69) mg/g for median (interquartile range) respectively. A total of 394 (20%) subjects had EiA; ACR rose from normal rest values (0.79 mg/g) to 52.28 mg/g after exercise (P < 0.001); this effect was not shown for the rest of the study population. EiA was related to higher prevalence of MS (13.8% vs. 27.1%, P < 0.001), higher metabolic equivalents (P < 0.001), higher baseline blood pressure (P < 0.001), and higher levels of fasting plasma glucose, triglycerides, and body mass index (P < 0.001). Multivariate binary logistic regression model showed that subjects with MS were 98% more likely to have EiA (95% confidence interval: 1.13–3.46, P = 0.016). In conclusion, EiA in the absence of baseline MA is independently related to MS.

Original languageEnglish
Pages (from-to)F1192-F1196
JournalAmerican Journal of Physiology - Renal Physiology
Volume310
Issue number11
DOIs
StatePublished - 1 Jun 2016
Externally publishedYes

Keywords

  • Exercise-induced albuminuria
  • Metabolic syndrome
  • Stress test

ASJC Scopus subject areas

  • Physiology
  • Urology

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