Experience in the treatment of localized carcinoma of the prostate by definitive external irradiation

A. Kuten; S. Nitetzky; M. Tatcher; Y. Cohen; E. Robinson

doi:10.1007/BF02559744

Experience in the treatment of localized carcinoma of the prostate by definitive external irradiation

A. Kuten, S. Nitetzky, M. Tatcher, Y. Cohen, E. Robinson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

One hundred and sixteen patients with stages A₂, B, and C histologically proven adenocarcinoma of the prostate were treated by definitive radiation. They received first whole pelvic irradiation, 46 Gy in 23 treatments, followed by a prostatic "boost" of 20 Gy in 10 fractions. Five-year survival rates varied between 39 and 84%. Prophylactic hormonal manipulation and transurethral resection of the prostate (TURP) did not influence survival figures. Complications of radiotherapy were in an acceptable range. It is concluded that external beam irradiation is an effective, simple, and usually well-tolerated treatment modality for localized carcinoma of the prostate. Stage and degree of differentiation and response of the primary tumour to radiation are predictors of patient outcome. There is no advantage in prophylactic hormonal manipulation, and TURP does not influence survival according to our experience.

Original language	English
Pages (from-to)	325-332
Number of pages	8
Journal	International Urology and Nephrology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1007/BF02559744
State	Published - 1 May 1989
Externally published	Yes

ASJC Scopus subject areas

Nephrology
Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/BF02559744

Cite this

@article{e2708400edd840588fa48a51c29a50b7,

title = "Experience in the treatment of localized carcinoma of the prostate by definitive external irradiation",

abstract = "One hundred and sixteen patients with stages A2, B, and C histologically proven adenocarcinoma of the prostate were treated by definitive radiation. They received first whole pelvic irradiation, 46 Gy in 23 treatments, followed by a prostatic {"}boost{"} of 20 Gy in 10 fractions. Five-year survival rates varied between 39 and 84%. Prophylactic hormonal manipulation and transurethral resection of the prostate (TURP) did not influence survival figures. Complications of radiotherapy were in an acceptable range. It is concluded that external beam irradiation is an effective, simple, and usually well-tolerated treatment modality for localized carcinoma of the prostate. Stage and degree of differentiation and response of the primary tumour to radiation are predictors of patient outcome. There is no advantage in prophylactic hormonal manipulation, and TURP does not influence survival according to our experience.",

author = "A. Kuten and S. Nitetzky and M. Tatcher and Y. Cohen and E. Robinson",

year = "1989",

month = may,

day = "1",

doi = "10.1007/BF02559744",

language = "English",

volume = "21",

pages = "325--332",

journal = "International Urology and Nephrology",

issn = "0301-1623",

publisher = "Springer Netherlands",

number = "3",

}

TY - JOUR

T1 - Experience in the treatment of localized carcinoma of the prostate by definitive external irradiation

AU - Kuten, A.

AU - Nitetzky, S.

AU - Tatcher, M.

AU - Cohen, Y.

AU - Robinson, E.

PY - 1989/5/1

Y1 - 1989/5/1

N2 - One hundred and sixteen patients with stages A2, B, and C histologically proven adenocarcinoma of the prostate were treated by definitive radiation. They received first whole pelvic irradiation, 46 Gy in 23 treatments, followed by a prostatic "boost" of 20 Gy in 10 fractions. Five-year survival rates varied between 39 and 84%. Prophylactic hormonal manipulation and transurethral resection of the prostate (TURP) did not influence survival figures. Complications of radiotherapy were in an acceptable range. It is concluded that external beam irradiation is an effective, simple, and usually well-tolerated treatment modality for localized carcinoma of the prostate. Stage and degree of differentiation and response of the primary tumour to radiation are predictors of patient outcome. There is no advantage in prophylactic hormonal manipulation, and TURP does not influence survival according to our experience.

AB - One hundred and sixteen patients with stages A2, B, and C histologically proven adenocarcinoma of the prostate were treated by definitive radiation. They received first whole pelvic irradiation, 46 Gy in 23 treatments, followed by a prostatic "boost" of 20 Gy in 10 fractions. Five-year survival rates varied between 39 and 84%. Prophylactic hormonal manipulation and transurethral resection of the prostate (TURP) did not influence survival figures. Complications of radiotherapy were in an acceptable range. It is concluded that external beam irradiation is an effective, simple, and usually well-tolerated treatment modality for localized carcinoma of the prostate. Stage and degree of differentiation and response of the primary tumour to radiation are predictors of patient outcome. There is no advantage in prophylactic hormonal manipulation, and TURP does not influence survival according to our experience.

UR - http://www.scopus.com/inward/record.url?scp=0024400281&partnerID=8YFLogxK

U2 - 10.1007/BF02559744

DO - 10.1007/BF02559744

M3 - Article

AN - SCOPUS:0024400281

SN - 0301-1623

VL - 21

SP - 325

EP - 332

JO - International Urology and Nephrology

JF - International Urology and Nephrology

IS - 3

ER -

Experience in the treatment of localized carcinoma of the prostate by definitive external irradiation

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this