Exploring cargo transport mechanics in the type IV secretion systems

Jianxiong Li; Sharon G. Wolf; Michael Elbaum; Tzvi Tzfira

doi:10.1016/j.tim.2005.05.002

Exploring cargo transport mechanics in the type IV secretion systems

Jianxiong Li, Sharon G. Wolf, Michael Elbaum, Tzvi Tzfira

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

Type IV secretion systems (T4SSs) are used by various bacteria to deliver protein and DNA molecules to a wide range of target cells. These include systems that are directly involved in pathogenesis, such as the secretion of pertussis toxin by Bordetella pertussis into human cells and the delivery of single-stranded DNA (ssDNA) into plants by Agrobacterium. These complex systems are composed of proteins that span the bacterial cytoplasm. The Agrobacterium T4SS is composed of 12 virulence proteins and delivers its transferred ssDNA and several virulence protein substrates to a variety of eukaryotic cells. Recent studies on the Agrobacterium T4SS have revealed new information on the localization and structure of its proteins in the bacteria, the biochemical properties of its transport signal, the route of a DNA substrate through the secretion system, and the initial point of contact of the system with its host. These findings have expanded our knowledge and understanding of the still mostly obscure structure and function of the T4SSs.

Original language	English
Pages (from-to)	295-298
Number of pages	4
Journal	Trends in Microbiology
Volume	13
Issue number	7
DOIs	https://doi.org/10.1016/j.tim.2005.05.002
State	Published - 1 Jan 2005
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2005.05.002

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title = "Exploring cargo transport mechanics in the type IV secretion systems",

abstract = "Type IV secretion systems (T4SSs) are used by various bacteria to deliver protein and DNA molecules to a wide range of target cells. These include systems that are directly involved in pathogenesis, such as the secretion of pertussis toxin by Bordetella pertussis into human cells and the delivery of single-stranded DNA (ssDNA) into plants by Agrobacterium. These complex systems are composed of proteins that span the bacterial cytoplasm. The Agrobacterium T4SS is composed of 12 virulence proteins and delivers its transferred ssDNA and several virulence protein substrates to a variety of eukaryotic cells. Recent studies on the Agrobacterium T4SS have revealed new information on the localization and structure of its proteins in the bacteria, the biochemical properties of its transport signal, the route of a DNA substrate through the secretion system, and the initial point of contact of the system with its host. These findings have expanded our knowledge and understanding of the still mostly obscure structure and function of the T4SSs.",

author = "Jianxiong Li and Wolf, {Sharon G.} and Michael Elbaum and Tzvi Tzfira",

note = "Funding Information: We thank the authors cited in this work for their contribution to the figures and we apologize to those who were not cited due to space constraints. The work in our laboratories is supported by grants from the Human Frontiers Science Program (HFSP) to T.T. and M.E. and the US-Israel Bi-national Agricultural Research and Development Fund (BARD) to T.T., S.G.W. and M.E.",

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doi = "10.1016/j.tim.2005.05.002",

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T1 - Exploring cargo transport mechanics in the type IV secretion systems

AU - Li, Jianxiong

AU - Wolf, Sharon G.

AU - Elbaum, Michael

AU - Tzfira, Tzvi

N1 - Funding Information: We thank the authors cited in this work for their contribution to the figures and we apologize to those who were not cited due to space constraints. The work in our laboratories is supported by grants from the Human Frontiers Science Program (HFSP) to T.T. and M.E. and the US-Israel Bi-national Agricultural Research and Development Fund (BARD) to T.T., S.G.W. and M.E.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Type IV secretion systems (T4SSs) are used by various bacteria to deliver protein and DNA molecules to a wide range of target cells. These include systems that are directly involved in pathogenesis, such as the secretion of pertussis toxin by Bordetella pertussis into human cells and the delivery of single-stranded DNA (ssDNA) into plants by Agrobacterium. These complex systems are composed of proteins that span the bacterial cytoplasm. The Agrobacterium T4SS is composed of 12 virulence proteins and delivers its transferred ssDNA and several virulence protein substrates to a variety of eukaryotic cells. Recent studies on the Agrobacterium T4SS have revealed new information on the localization and structure of its proteins in the bacteria, the biochemical properties of its transport signal, the route of a DNA substrate through the secretion system, and the initial point of contact of the system with its host. These findings have expanded our knowledge and understanding of the still mostly obscure structure and function of the T4SSs.

AB - Type IV secretion systems (T4SSs) are used by various bacteria to deliver protein and DNA molecules to a wide range of target cells. These include systems that are directly involved in pathogenesis, such as the secretion of pertussis toxin by Bordetella pertussis into human cells and the delivery of single-stranded DNA (ssDNA) into plants by Agrobacterium. These complex systems are composed of proteins that span the bacterial cytoplasm. The Agrobacterium T4SS is composed of 12 virulence proteins and delivers its transferred ssDNA and several virulence protein substrates to a variety of eukaryotic cells. Recent studies on the Agrobacterium T4SS have revealed new information on the localization and structure of its proteins in the bacteria, the biochemical properties of its transport signal, the route of a DNA substrate through the secretion system, and the initial point of contact of the system with its host. These findings have expanded our knowledge and understanding of the still mostly obscure structure and function of the T4SSs.

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DO - 10.1016/j.tim.2005.05.002

M3 - Short survey

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AN - SCOPUS:21244496305

SN - 0966-842X

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SP - 295

EP - 298

JO - Trends in Microbiology

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IS - 7

ER -

Exploring cargo transport mechanics in the type IV secretion systems

Abstract

ASJC Scopus subject areas

UN SDGs

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