Exposing and modeling underlying mechanisms in ALS with machine learning

Jonathan Gordon, Boaz Lerner

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We develop methodologies and apply machine-learning algorithms to a database of ALS patients to expose and model underlying mechanisms and relations in the disease. We view the disease state as an ordinal variable (with values between 4 for normal function and 0 for complete loss of function), and show that ordinal classification applied to the data has an advantage over classification that does not utilize the ordinal nature of the domain. To identify important physiological and lab test variables in relation to patient functionality, we rank variables with a decision tree that predicts future disease state using current and past variable instantiations. In addition, we cluster data of patient functionalities in performing daily tasks into higher level groupings of body segments and show how certain variables relate more concretely to certain groupings than to others, thus reducing the dimensionality of the disease state representation in a natural manner that was found to be medically interpretable. Finally, we learn Bayesian networks to detect predictors within the Markov blanket of the disease-state variable and to expose relations among the predictors and with the disease state, as well as to identify value combinations of the predictors that distinguish severe and mild patients.

Original languageEnglish
Title of host publication2016 23rd International Conference on Pattern Recognition, ICPR 2016
PublisherInstitute of Electrical and Electronics Engineers
Pages2168-2173
Number of pages6
ISBN (Electronic)9781509048472
DOIs
StatePublished - 1 Jan 2016
Event23rd International Conference on Pattern Recognition, ICPR 2016 - Cancun, Mexico
Duration: 4 Dec 20168 Dec 2016

Publication series

NameProceedings - International Conference on Pattern Recognition
Volume0
ISSN (Print)1051-4651

Conference

Conference23rd International Conference on Pattern Recognition, ICPR 2016
Country/TerritoryMexico
CityCancun
Period4/12/168/12/16

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition

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