Exposure to Fine Particulate Matter and Ovarian Reserve among Women from a Fertility Clinic

Audrey J. Gaskins; Lidia Mínguez-Alarcón; Kelvin C. Fong; Sarah Abdelmessih; Brent A. Coull; Jorge E. Chavarro; Joel Schwartz; Itai Kloog; Irene Souter; Russ Hauser; Francine Laden

doi:10.1097/EDE.0000000000001029

Exposure to Fine Particulate Matter and Ovarian Reserve among Women from a Fertility Clinic

Audrey J. Gaskins, Lidia Mínguez-Alarcón, Kelvin C. Fong, Sarah Abdelmessih, Brent A. Coull, Jorge E. Chavarro, Joel Schwartz, Itai Kloog, Irene Souter, Russ Hauser, Francine Laden

Department of Environmental, Geoinformatic and Urban Planning Sciences

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background: An increasing number of studies have linked air pollution to decreased fertility. Whether this is due to an effect on ovarian reserve is unknown. Method: Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004-2015) who had a measured antral follicle count. Validated spatiotemporal models estimated daily particulate matter <2.5 µg/m³ (PM^2.5) (based on residential address) for the 3 months before the antral follicle count. We analyzed associations with Poisson regression. Results: Every 2 µg/m³ increase in estimated PM^2.5 exposure was associated with a-7.2% (95% confidence interval =-10.4%,-3.8%) lower antral follicle count adjusting for age, body mass index, smoking status, and year and season of the count. The association of PM^2.5 with antral follicle count was stronger among women with female factor infertility (-16.3% per 2 µg/m³). Conclusions: Among women from an infertility clinic, higher PM^2.5 exposure was associated with lower ovarian reserve, raising concern that air pollution may accelerate reproductive aging.

Original language	English
Pages (from-to)	486-491
Number of pages	6
Journal	Epidemiology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1097/EDE.0000000000001029
State	Published - 1 Jul 2019

Keywords

Air pollution
Fecundity
Fertility
Ovarian reserve

ASJC Scopus subject areas

Epidemiology

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10.1097/EDE.0000000000001029

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title = "Exposure to Fine Particulate Matter and Ovarian Reserve among Women from a Fertility Clinic",

abstract = "Background: An increasing number of studies have linked air pollution to decreased fertility. Whether this is due to an effect on ovarian reserve is unknown. Method: Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004-2015) who had a measured antral follicle count. Validated spatiotemporal models estimated daily particulate matter <2.5 µg/m3 (PM2.5) (based on residential address) for the 3 months before the antral follicle count. We analyzed associations with Poisson regression. Results: Every 2 µg/m3 increase in estimated PM2.5 exposure was associated with a-7.2% (95% confidence interval =-10.4%,-3.8%) lower antral follicle count adjusting for age, body mass index, smoking status, and year and season of the count. The association of PM2.5 with antral follicle count was stronger among women with female factor infertility (-16.3% per 2 µg/m3). Conclusions: Among women from an infertility clinic, higher PM2.5 exposure was associated with lower ovarian reserve, raising concern that air pollution may accelerate reproductive aging.",

keywords = "Air pollution, Fecundity, Fertility, Ovarian reserve",

author = "Gaskins, {Audrey J.} and Lidia M{\'i}nguez-Alarc{\'o}n and Fong, {Kelvin C.} and Sarah Abdelmessih and Coull, {Brent A.} and Chavarro, {Jorge E.} and Joel Schwartz and Itai Kloog and Irene Souter and Russ Hauser and Francine Laden",

note = "Funding Information: Supported by grants ES009718, ES022955, ES000002, and K99ES026648 from the National Institute of Environmental Health Sciences (NIEHS). This publication was also made possible by the U.S. Environmental Pro-tection Agency (U.S. EPA): RD-834798 and RD-83587201. Its contents are solely the responsibility of the grantee and do not necessarily repre-sent the official views of the U.S. EPA. Further, the U.S. EPA does not endorse the purchase of any commercial products or services mentioned in the publication. Publisher Copyright: {\textcopyright} 2019 Lippincott Williams and Wilkins. All rights reserved.",

year = "2019",

month = jul,

day = "1",

doi = "10.1097/EDE.0000000000001029",

language = "English",

volume = "30",

pages = "486--491",

journal = "Epidemiology",

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publisher = "Lippincott Williams and Wilkins Ltd.",

number = "4",

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T1 - Exposure to Fine Particulate Matter and Ovarian Reserve among Women from a Fertility Clinic

AU - Gaskins, Audrey J.

AU - Mínguez-Alarcón, Lidia

AU - Fong, Kelvin C.

AU - Abdelmessih, Sarah

AU - Coull, Brent A.

AU - Chavarro, Jorge E.

AU - Schwartz, Joel

AU - Kloog, Itai

AU - Souter, Irene

AU - Hauser, Russ

AU - Laden, Francine

N1 - Funding Information: Supported by grants ES009718, ES022955, ES000002, and K99ES026648 from the National Institute of Environmental Health Sciences (NIEHS). This publication was also made possible by the U.S. Environmental Pro-tection Agency (U.S. EPA): RD-834798 and RD-83587201. Its contents are solely the responsibility of the grantee and do not necessarily repre-sent the official views of the U.S. EPA. Further, the U.S. EPA does not endorse the purchase of any commercial products or services mentioned in the publication. Publisher Copyright: © 2019 Lippincott Williams and Wilkins. All rights reserved.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: An increasing number of studies have linked air pollution to decreased fertility. Whether this is due to an effect on ovarian reserve is unknown. Method: Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004-2015) who had a measured antral follicle count. Validated spatiotemporal models estimated daily particulate matter <2.5 µg/m3 (PM2.5) (based on residential address) for the 3 months before the antral follicle count. We analyzed associations with Poisson regression. Results: Every 2 µg/m3 increase in estimated PM2.5 exposure was associated with a-7.2% (95% confidence interval =-10.4%,-3.8%) lower antral follicle count adjusting for age, body mass index, smoking status, and year and season of the count. The association of PM2.5 with antral follicle count was stronger among women with female factor infertility (-16.3% per 2 µg/m3). Conclusions: Among women from an infertility clinic, higher PM2.5 exposure was associated with lower ovarian reserve, raising concern that air pollution may accelerate reproductive aging.

AB - Background: An increasing number of studies have linked air pollution to decreased fertility. Whether this is due to an effect on ovarian reserve is unknown. Method: Our study included 632 women attending the Massachusetts General Hospital Fertility Center (2004-2015) who had a measured antral follicle count. Validated spatiotemporal models estimated daily particulate matter <2.5 µg/m3 (PM2.5) (based on residential address) for the 3 months before the antral follicle count. We analyzed associations with Poisson regression. Results: Every 2 µg/m3 increase in estimated PM2.5 exposure was associated with a-7.2% (95% confidence interval =-10.4%,-3.8%) lower antral follicle count adjusting for age, body mass index, smoking status, and year and season of the count. The association of PM2.5 with antral follicle count was stronger among women with female factor infertility (-16.3% per 2 µg/m3). Conclusions: Among women from an infertility clinic, higher PM2.5 exposure was associated with lower ovarian reserve, raising concern that air pollution may accelerate reproductive aging.

KW - Air pollution

KW - Fecundity

KW - Fertility

KW - Ovarian reserve

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DO - 10.1097/EDE.0000000000001029

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AN - SCOPUS:85067190977

SN - 1044-3983

VL - 30

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JO - Epidemiology

JF - Epidemiology

IS - 4

ER -

Exposure to Fine Particulate Matter and Ovarian Reserve among Women from a Fertility Clinic

Abstract

Keywords

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