TY - JOUR
T1 - Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder
AU - Huberman Samuel, Maayan
AU - Meiri, Gal
AU - Dinstein, Ilan
AU - Flusser, Hagit
AU - Michaelovski, Analiya
AU - Bashiri, Asher
AU - Menashe, Idan
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026–2.302, and aOR = 1.692; 95% CI 1.057–2.709, pdiff = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD.
AB - Cesarean section (CS) has been consistently associated with susceptibility to autism spectrum disorder (ASD), however, the underlying mechanism for this association remains vague. Here, we studied various pre-peri-and-neonatal factors among 347 children with ASD, 117 children with other developmental delays (DD), and 2226 age, sex and ethnicity matched controls. We found that CS is significantly associated with an increased risk of ASD but not DD (p = 0.019 and p = 0.540 respectively). Furthermore, we show that only CS performed with general anesthesia (GA) elevated the risk of ASD with no significant difference between indicated and non-indicated surgeries (aOR = 1.537; 95% CI 1.026–2.302, and aOR = 1.692; 95% CI 1.057–2.709, pdiff = 0.865). We therefore suggest that exposure to GA during CS may explain the association between CS and ASD.
KW - Autism spectrum disorder
KW - Cesarean section
KW - General anesthesia
UR - http://www.scopus.com/inward/record.url?scp=85065323883&partnerID=8YFLogxK
U2 - 10.1007/s10803-019-04034-9
DO - 10.1007/s10803-019-04034-9
M3 - Article
C2 - 31053992
AN - SCOPUS:85065323883
SN - 0162-3257
VL - 49
SP - 3127
EP - 3135
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 8
ER -