Expression of CD24 on CD19-CD79a+ early B-cell progenitors in human bone marrow

Elena Israel, Joseph Kapelushnik, Tikva Yermiahu, Itai Levi, Isaak Yaniv, Ofer Shpilberg, George Shubinsky

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

CD24 is a surface marker expressed in immature and mature B cells and involved in cellular adhesion and apoptosis. There are no data, which delineate the stage in early development of human B cells, which marks the expression of CD24. We studied lymphopoiesis in normal pediatric bone marrow (BM) and found that 1.5 ± 0.2% of WBC were CD24+ lymphocytes which did not express CD19. A significant fraction of these cells expressed low levels of CD45 (CD19-CD24+CD45low cells). Small numbers of CD19-CD24+CD45low cells were found in the regenerating BM of children with acute lymphoblastic leukemia after the completion of chemotherapy and in normal adult BM. Flow cytometric analyses have shown that CD19-CD24+CD45low lymphocytes express CD10, CD34, CD79a, CD179a (VpreB), and TdT markers, i.e., displayed antigenic properties of early B-cell progenitors. Our data indicate that CD19- early B-cell progenitors in human BM express CD24, and that the expression of CD24 in human B-cell development precedes the expression of CD19.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalCellular Immunology
Volume236
Issue number1-2
DOIs
StatePublished - 1 Jul 2005

Keywords

  • B lymphocyte maturation
  • CD24
  • Early B-cell progenitors
  • Human bone marrow

ASJC Scopus subject areas

  • Immunology

Fingerprint

Dive into the research topics of 'Expression of CD24 on CD19-CD79a+ early B-cell progenitors in human bone marrow'. Together they form a unique fingerprint.

Cite this