@article{28143996cd3a4c1e826fe2229948252b,
title = "External validation of the SOX-PTS score in a prospective multicenter trial of patients with proximal deep vein thrombosis",
abstract = "Background: Using data from the SOX Trial, we recently developed a clinical prediction model for occurrence of the postthrombotic syndrome (PTS) after proximal deep vein thrombosis (DVT), termed the SOX-PTS score. The score includes anatomical extent of DVT; body mass index; and baseline Villalta score. Objective: To externally validate the SOX-PTS score. Methods: Logistic regression analysis of data from the ATTRACT Trial that evaluated pharmacomechanical catheter directed thrombolysis in patients with proximal DVT. The primary outcome was the occurrence of PTS (defined as Villalta score ≥ 5) from 6 to 24 months after DVT. Secondary outcomes included moderate-severe PTS (Villalta scale ≥ 10) and severe PTS (Villalta scale ≥ 14). Predictive performance was assessed by discrimination and calibration. An updated score was evaluated in an exploratory analysis. Results: Six hundred and ninety-one ATTRACT patients were included, of whom 328 (47%) developed PTS. The c-statistic was 0.63; 95% confidence interval (CI) 0.59-0.67 for PTS. The model's performance appeared to be better for the outcomes moderate to severe PTS and severe PTS (c-statistic 0.67; 95% CI 0.62-0.72 for moderate-severe PTS and 0.70; 0.64-0.77 for severe PTS). An updated model with age as an additional variable performed similarly to the original model. Conclusion: We externally validated the SOX-PTS score for estimating the risk of developing PTS, moderate to severe PTS, and severe PTS, in patients with proximal DVT. The score may be useful to predict PTS at the time of DVT diagnosis. Further external validation in different patient cohorts is required.",
keywords = "body mass index, clinical prediction rule, deep vein thrombosis, iliac vein, postthrombotic syndrome",
author = "{for the ATTRACT Trial Investigators} and Anat Rabinovich and Gu, {Chu Shu} and Suresh Vedantham and Clive Kearon and Goldhaber, {Samuel Z.} and Gornik, {Heather L.} and Kahn, {Susan R.}",
note = "Funding Information: The ATTRACT Trial was supported by grants from The National Heart, Lung, and Blood Institute (NHLBI) for the clinical coordinating center (U01-HL088476 to Washington University in St. Louis) and data coordinating center (U01-HL088118 to McMaster University, Hamilton, ON); the Washington University Center for Translational Therapies in Thrombosis, which is supported by a grant from the NHLBI (U54-HL112303); the Washington University Institute of Clinical and Translational Sciences, which is supported by a grant from the National Center for the Advancement of Translational Sciences (UL1-TR00044810); Boston Scientific; Covidien (now Medtronic); Genentech; The Society of Interventional Radiology Foundation. Dr Kahn is supported by A Tier 1 Canada Research Chair. Dr Kearon is supported by The Jack Hirsh Professorship in Thromboembolism. Drs. Kahn and Kearon are investigators of the CanVECTOR Network, which receives grant funding from The Canadian Institutes of Health Research (funding reference: CDT-142654). Funding Information: The ATTRACT Trial was supported by grants from The National Heart, Lung, and Blood Institute (NHLBI) for the clinical coordinating center (U01‐HL088476 to Washington University in St. Louis) and data coordinating center (U01‐HL088118 to McMaster University, Hamilton, ON); the Washington University Center for Translational Therapies in Thrombosis, which is supported by a grant from the NHLBI (U54‐HL112303); the Washington University Institute of Clinical and Translational Sciences, which is supported by a grant from the National Center for the Advancement of Translational Sciences (UL1‐TR00044810); Boston Scientific; Covidien (now Medtronic); Genentech; The Society of Interventional Radiology Foundation. Dr Kahn is supported by A Tier 1 Canada Research Chair. Dr Kearon is supported by The Jack Hirsh Professorship in Thromboembolism. Drs. Kahn and Kearon are investigators of the CanVECTOR Network, which receives grant funding from The Canadian Institutes of Health Research (funding reference: CDT‐142654). Publisher Copyright: {\textcopyright} 2020 International Society on Thrombosis and Haemostasis",
year = "2020",
month = jun,
day = "1",
doi = "10.1111/jth.14791",
language = "English",
volume = "18",
pages = "1381--1389",
journal = "Journal of Thrombosis and Haemostasis",
issn = "1538-7933",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",
}