Extracorporeal methods of blood glutamate scavenging: A novel therapeutic modality

Agzam Zhumadilov, Matthew Boyko, Shaun E. Gruenbaum, Evgeny Brotfain, Federico Bilotta, Alexander Zlotnik

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Pathologically elevated glutamate concentrations in the brain's extracellular fluid are associated with several acute and chronic brain insults. Studies have demonstrated that by decreasing the concentration of glutamate in the blood, thereby increasing the concentration gradient between the brain and the blood, the rate of brain-to-blood glutamate efflux can be increased. Blood glutamate scavengers, pyruvate and oxaloacetate have shown great promise in providing neuroprotection in many animal models of acute brain insults. However, glutamate scavengers' potential systemic toxicity, side effects and pharmacokinetic properties may limit their use in clinical practice. In contrast, extracorporeal methods of blood glutamate reduction, in which glutamate is filtered from the blood and eliminated, may be an advantageous adjunct in treating acute brain insults. Here, we review the current evidence for the glutamate-lowering effects of hemodialysis, peritoneal dialysis and hemofiltration. The evidence reviewed here highlights the need for clinical trials.

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalExpert Review of Neurotherapeutics
Issue number5
StatePublished - 1 May 2015


  • blood glutamate scavenging
  • extracorporeal methods
  • hemodialysis
  • hemofiltration
  • neuroprotection
  • peritoneal dialysis

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Pharmacology (medical)


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