TY - JOUR
T1 - Extremely small-magnitude accelerations enhance bone regeneration
T2 - A preliminary study
AU - Hwang, Soon Jung
AU - Lublinsky, Svetlana
AU - Seo, Young Kwon
AU - Kim, In Sook
AU - Judex, Stefan
N1 - Funding Information:
One or more of the authors (SJ) received funding from the Wallace H. Coulter Foundation, the Whitaker Foundation, and the National Science Foundation. Each author certifies that the Institutional Animal Care and Use Committee at the State University of New York at Stony Brook approved the animal protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - High-frequency, low-magnitude accelerations can be anabolic and anticatabolic to bone. We tested the hypothesis that application of these mechanical signals can accelerate bone regeneration in scaffolded and nonscaffolded calvarial defects. The cranium of experimental rats (n = 8) in which the 5-mm bilateral defects either contained a collagen scaffold or were left empty received oscillatory accelerations (45 Hz, 0.4 g) for 20 minutes per day for 3 weeks. Compared with scaffolded defects in the untreated control group (n = 6), defects with a scaffold and subject to oscillatory accelerations had a 265% greater fractional bone defect area 4 weeks after the surgery. After 8 weeks of healing (1-week recovery, 3 weeks of stimulation, 4 weeks without stimulation), the area (181%), volume (137%), and thickness (53%) of the regenerating tissue in the scaffolded defect were greater in experimental than in control animals. In unscaffolded defects, mechanical stimulation induced an 84% greater bone volume and a 33% greater thickness in the defect. These data provide preliminary evidence that extremely low-level, high-frequency accelerations can enhance osseous regenerative processes, particularly in the presence of a supporting scaffold.
AB - High-frequency, low-magnitude accelerations can be anabolic and anticatabolic to bone. We tested the hypothesis that application of these mechanical signals can accelerate bone regeneration in scaffolded and nonscaffolded calvarial defects. The cranium of experimental rats (n = 8) in which the 5-mm bilateral defects either contained a collagen scaffold or were left empty received oscillatory accelerations (45 Hz, 0.4 g) for 20 minutes per day for 3 weeks. Compared with scaffolded defects in the untreated control group (n = 6), defects with a scaffold and subject to oscillatory accelerations had a 265% greater fractional bone defect area 4 weeks after the surgery. After 8 weeks of healing (1-week recovery, 3 weeks of stimulation, 4 weeks without stimulation), the area (181%), volume (137%), and thickness (53%) of the regenerating tissue in the scaffolded defect were greater in experimental than in control animals. In unscaffolded defects, mechanical stimulation induced an 84% greater bone volume and a 33% greater thickness in the defect. These data provide preliminary evidence that extremely low-level, high-frequency accelerations can enhance osseous regenerative processes, particularly in the presence of a supporting scaffold.
UR - http://www.scopus.com/inward/record.url?scp=62449274597&partnerID=8YFLogxK
U2 - 10.1007/s11999-008-0552-5
DO - 10.1007/s11999-008-0552-5
M3 - Article
C2 - 18855088
AN - SCOPUS:62449274597
SN - 0009-921X
VL - 467
SP - 1083
EP - 1091
JO - Clinical Orthopaedics and Related Research
JF - Clinical Orthopaedics and Related Research
IS - 4
ER -