Fabrication of an electrochemical sensor based on electroreduced graphene oxide for the determination of valganciclovir

Shankar Narayan Prashanth, Nagappa Laxman Teradal, Jaldappagari Seetharamappa, Ashis Kumar Satpati

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In the present work, we have synthesized and characterized graphene oxide and utilized to fabricate an electrochemical sensor. Electrochemically reduced graphene (ERGO) film was used for the electrochemical investigation of an antiviral drug, valganciclovir (VGCV) for the first time. The peak current was found to be enhanced significantly at ERGO film compared to that at bare GCE. Effect of accumulation time, different pH and scan rate was investigated and various electrochemical parameters were evaluated. Probable mechanism for electrooxidation was proposed based on the experimental results. A differential pulse voltammetric method was developed for the determination of VGCV in bulk and pharmaceutical formulations. Linear relationship was noticed between the peak current and concentration in the range of 15 nM -35 μM with the LOD of 3.10 nM and the LOQ of 10.33 nM. The proposed method is simple, fast and inexpensive and hence, could be readily adopted for quality control.

Original languageEnglish
Pages (from-to)B117-B122
JournalJournal of the Electrochemical Society
Volume161
Issue number6
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Renewable Energy, Sustainability and the Environment
  • Surfaces, Coatings and Films
  • Electrochemistry
  • Materials Chemistry

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