TY - JOUR
T1 - Fabrication of the electrochemically reduced graphene oxide-bismuth nanoparticles composite and its analytical application for an anticancer drug gemcitabine
AU - Tandel, Ranjita
AU - Teradal, Nagappa
AU - Satpati, Ashis
AU - Jaldappagari, Seetharamappa
N1 - Publisher Copyright:
© 2016 Seetharamappa Jaldappagari
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The present study explores an electroreduced graphene oxide-bismuth nanoparticles composite (Er-GOBi) as an electrochemical sensor for the determination of an anticancer drug, gemcitabine hydrochloride (GMB). The Er-GOBi interface was prepared by drop casting of bismuth nitrate-graphene oxide suspension on a glassy carbon electrode (GCE) followed by electro-reduction in the potential range of 0.6 V to −1.7 V. SEM, FTIR, EDAX and AFM techniques were employed for the characterization of prepared materials. Cyclic voltammetric and electrochemical impedance spectroscopic methods were used to understand the charge transfer properties of stepwise modification of Er-GOBi/GCE. GMB exhibited an irreversible oxidation peak at 1.144 V on Er-GOBi/GCE in phosphate buffer of pH 3. A 100-fold enhanced oxidation peak current was observed at Er-GOBi/GCE when compared to that at bare GCE. Sensing performance of ErGO-Bi/GCE was optimized by varying peak current dependent parameters. Linear relationship between the peak current and concentration of GMB was observed in the range of 0.1–51.1 μmol/L in differential pulse voltammetric method and 2.1–61.1 μmol/L in linear sweep voltammetric method. The practical utility of the proposed sensor, Er-GOBi/GCE was demonstrated by determining GMB in pharmaceutical formulations and spiked urine samples.
AB - The present study explores an electroreduced graphene oxide-bismuth nanoparticles composite (Er-GOBi) as an electrochemical sensor for the determination of an anticancer drug, gemcitabine hydrochloride (GMB). The Er-GOBi interface was prepared by drop casting of bismuth nitrate-graphene oxide suspension on a glassy carbon electrode (GCE) followed by electro-reduction in the potential range of 0.6 V to −1.7 V. SEM, FTIR, EDAX and AFM techniques were employed for the characterization of prepared materials. Cyclic voltammetric and electrochemical impedance spectroscopic methods were used to understand the charge transfer properties of stepwise modification of Er-GOBi/GCE. GMB exhibited an irreversible oxidation peak at 1.144 V on Er-GOBi/GCE in phosphate buffer of pH 3. A 100-fold enhanced oxidation peak current was observed at Er-GOBi/GCE when compared to that at bare GCE. Sensing performance of ErGO-Bi/GCE was optimized by varying peak current dependent parameters. Linear relationship between the peak current and concentration of GMB was observed in the range of 0.1–51.1 μmol/L in differential pulse voltammetric method and 2.1–61.1 μmol/L in linear sweep voltammetric method. The practical utility of the proposed sensor, Er-GOBi/GCE was demonstrated by determining GMB in pharmaceutical formulations and spiked urine samples.
KW - Electrochemical sensor
KW - Gemcitabine
KW - Graphene oxide
KW - Nanocomposite
KW - Pharmaceutical formulations
UR - http://www.scopus.com/inward/record.url?scp=85008336863&partnerID=8YFLogxK
U2 - 10.1016/j.cclet.2016.11.028
DO - 10.1016/j.cclet.2016.11.028
M3 - Article
AN - SCOPUS:85008336863
SN - 1001-8417
VL - 28
SP - 1429
EP - 1437
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
IS - 7
ER -
