Factors associated with changes in posterior corneal surface following laser-assisted in situ keratomileusis

Achia Nemet, Dror Ben Ephraim Noyman, Waseem Nasser, Tzahi Sela, Gur Munzer, Shawn Sapir, Michael Mimouni, Igor Kaiserman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Purpose: To identify factors associated with changes in the posterior corneal curvature following laser-assisted in situ keratomileusis (LASIK). Methods: This retrospective study included myopic astigmatic eyes that underwent LASIK between January and December 2013 at Care-Vision Laser Center, Tel-Aviv, Israel. The average posterior keratometry was measured with the Sirius device at a radius of 3 mm from the center. The correlations between the surgically induced change in average posterior keratometry and preoperative parameters such as preoperative sphere, cylinder, spherical equivalent, central corneal thickness (CCT), refraction, Baiocchi Calossi Versaci (BCV) index, ablation depth, percent of tissue altered (PTA), and residual stromal bed (RSB) are reported. Results: A total of 115 eyes with a mean age of 32.5 ± 8.3 years (range 22–56 years) were included. Central corneal thickness (p < 0.005), preoperative sphere (p < 0.001), spherical equivalent (p < 0.005), and preoperative posterior inferior/superior ratio (p < 0.05) were all significantly correlated with the percentage of change in the mean posterior K. According to ranked stepwise multiple regression analysis, 22% of the variance of change in posterior K could be explained by the examined factors. The factors that remained significant were the percentage of change in posterior inferior/superior ratio, preoperative subjective sphere, and preoperative mean posterior K (for all, p < 0.001). Conclusions: The percentage of change in posterior inferior/superior ratio, subjective sphere, and preoperative mean posterior K are all correlated with change in the mean posterior K after LASIK. Understanding of the variables that can influence posterior corneal changes following refractive surgery may play a role in the prevention of iatrogenic keratectasia. (Figure presented.)

    Original languageEnglish
    Pages (from-to)1215-1220
    Number of pages6
    JournalGraefe's Archive for Clinical and Experimental Ophthalmology
    Volume262
    Issue number4
    DOIs
    StatePublished - 1 Apr 2024

    Keywords

    • Keratectasia, Refractive surgery
    • LASIK
    • Percent tissue altered
    • Posterior cornea

    ASJC Scopus subject areas

    • Sensory Systems
    • Cellular and Molecular Neuroscience
    • Ophthalmology

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