Factors associated with drug survival of methotrexate and acitretin in patients with psoriasis

Guy Shalom, Devy Zisman, Ilana Harman-Boehm, Haim Biterman, Sari Greenberg-Dotan, Ilya Polishchuk, Hadas Moser, Tamar Freud, Ilan Feldhamer, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Drug survival has recently become an important clinical issue in psoriasis. However, there has been little research into factors associated with drug survival of methotrexate and acitretin. The aim of this study was to investigate factors associated with drug survival of methotrexate and acitretin treatment for psoriasis. Survival analysis was performed in patients who received methotrexate or acitretin for the treatment of psoriasis, drawn from the Clalit Health Services database. Investigated factors included demographic variables, obesity, metabolic syndrome, psoriatic arthritis, administration route and folic acid supplementation. Among 6,256 patients, factors associated with treatment drop-out were: younger age (p <0.001) and psoriatic arthritis (acitretin p < 0.001). For methotrexate, metabolic syndrome (p = 0.033), intramuscular administration route of injection (p <0.001) and lack of folic acid supplementation (p <0.001) were associated with treatment drop-out. In patients with psoriasis, some ancillary factors may modify the drug survival of acitretin and methotrexate.

Original languageEnglish
Pages (from-to)973-977
Number of pages5
JournalActa Dermato-Venereologica
Volume95
Issue number8
DOIs
StatePublished - 1 Nov 2015

Keywords

  • Acitretin
  • Drug survival
  • Folic acid
  • Methotrexate
  • Psoriasis
  • Traditional systemic agents

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