FAILURE OF ADDITION OF LITHIUM TO IMIPRAMINE TO ENHANCE ACTIVITY IN RATS OR MOOD IN NORMAL VOLUNTEERS

Jonathan Benjamin, RH Belmaker, Yuli Berzovsky, Arsen Revasov, Ora Kofman

Research output: Contribution to journalArticlepeer-review

Abstract

Lithium powerfully augments the effects of imipramine in resistant depression. We treated four groups of rats for five weeks with (1) saline alone, (2) saline followed by lithium, (3) imipramine alone, and (4) imipramine followed by lithium. There was no augmentation of activity by lithium. Normal human volunteers took imipramine 75 mg daily for three weeks, followed by imipramine 75 mg daily together with lithium 900 mg daily for another ten days. There was no elevation of mood after the addition of lithium. Lithium augmentation of antidepressants apparently requires a pre‐existing neurochemical‐behavioral disturbance. 1992 Nordic Pharmacological Society

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalBasic and Clinical Pharmacology and Toxicology
Volume71
DOIs
StatePublished - 1 Jan 1992

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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