FAILURE OF ADDITION OF LITHIUM TO IMIPRAMINE TO ENHANCE ACTIVITY IN RATS OR MOOD IN NORMAL VOLUNTEERS

Jonathan Benjamin; RH Belmaker; Yuli Berzovsky; Arsen Revasov; Ora Kofman

doi:10.1111/j.1600-0773.1992.tb01625.x

FAILURE OF ADDITION OF LITHIUM TO IMIPRAMINE TO ENHANCE ACTIVITY IN RATS OR MOOD IN NORMAL VOLUNTEERS

Jonathan Benjamin, RH Belmaker, Yuli Berzovsky, Arsen Revasov, Ora Kofman

Department of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Lithium powerfully augments the effects of imipramine in resistant depression. We treated four groups of rats for five weeks with (1) saline alone, (2) saline followed by lithium, (3) imipramine alone, and (4) imipramine followed by lithium. There was no augmentation of activity by lithium. Normal human volunteers took imipramine 75 mg daily for three weeks, followed by imipramine 75 mg daily together with lithium 900 mg daily for another ten days. There was no elevation of mood after the addition of lithium. Lithium augmentation of antidepressants apparently requires a pre‐existing neurochemical‐behavioral disturbance. 1992 Nordic Pharmacological Society

Original language	English
Pages (from-to)	18-25
Number of pages	8
Journal	Basic and Clinical Pharmacology and Toxicology
Volume	71
DOIs	https://doi.org/10.1111/j.1600-0773.1992.tb01625.x
State	Published - 1 Jan 1992

ASJC Scopus subject areas

Toxicology
Pharmacology
Health, Toxicology and Mutagenesis

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10.1111/j.1600-0773.1992.tb01625.x

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abstract = "Lithium powerfully augments the effects of imipramine in resistant depression. We treated four groups of rats for five weeks with (1) saline alone, (2) saline followed by lithium, (3) imipramine alone, and (4) imipramine followed by lithium. There was no augmentation of activity by lithium. Normal human volunteers took imipramine 75 mg daily for three weeks, followed by imipramine 75 mg daily together with lithium 900 mg daily for another ten days. There was no elevation of mood after the addition of lithium. Lithium augmentation of antidepressants apparently requires a pre‐existing neurochemical‐behavioral disturbance. 1992 Nordic Pharmacological Society",

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AU - Berzovsky, Yuli

AU - Revasov, Arsen

AU - Kofman, Ora

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AB - Lithium powerfully augments the effects of imipramine in resistant depression. We treated four groups of rats for five weeks with (1) saline alone, (2) saline followed by lithium, (3) imipramine alone, and (4) imipramine followed by lithium. There was no augmentation of activity by lithium. Normal human volunteers took imipramine 75 mg daily for three weeks, followed by imipramine 75 mg daily together with lithium 900 mg daily for another ten days. There was no elevation of mood after the addition of lithium. Lithium augmentation of antidepressants apparently requires a pre‐existing neurochemical‐behavioral disturbance. 1992 Nordic Pharmacological Society

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FAILURE OF ADDITION OF LITHIUM TO IMIPRAMINE TO ENHANCE ACTIVITY IN RATS OR MOOD IN NORMAL VOLUNTEERS

Abstract

ASJC Scopus subject areas

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