Familial mediterranean fever in two bedouin families: Mutation analysis and disease severity

Joseph Press, Yael Shinar, Pnina Langevitz, Avi Livneh, Mordehai Pras, Dan Buskila

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disease prevalent among non-Ashkenazi Jews, Armenians, Arabs, and Turks. The Bedouin are nomad Arab tribes residing in desert margins of the Middle East and Arabia. FMF is quite rare in Bedouins, and here we report on two Bedouin families from southern Israel suffering from this disorder. The MEFV mutations found in the Bedouin patients M694I, V726A, and E148Q are consistent with their Arab origin. The disease severity score showed a mild to moderate severity disease in six patients. The Bedouins, leading a unique nomadic life, may prove instrumental in unraveling the role of environmental factors in the course and severity of FMF. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalAmerican Journal of Medical Genetics
Volume92
Issue number4
DOIs
StatePublished - 5 Jun 2000
Externally publishedYes

Keywords

  • Bedouins
  • FMF
  • MEFV
  • Mutation analysis

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