Familial studies on the occurrence of natural autoantibodies

O. Yadin, B. Sarov, L. Naggan, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Natural autoantibodies are often incidentally found in healthy individuals who are not first-degree relatives of known patients with autoimmune diseases. In an attempt to examine whether there exists a familial tendency in the production of such natural autoantibodies, 134 healthy members of 32 families were examined for antibodies against ss-DNA, ds-DNA, poly (I), poly (G), cardiolipin, histones, Sm, RNP, SS-A (Ro) and SS-B (La), using an enzyme-linked immunosorbent assay. Only 16 of the 134 subjects (11.9%) were found to possess autoantobodies in their sera in a titer exceeding the mean by 3 SD, and none of the 'positive' subjects were related. We conclude that in contrast to the familial occurrence of the autoantibodies of first-degree relatives of patients with autoimmune disease, there is no familial tendency in the occurrence of natural autoantibodies.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalNatural Immunity and Cell Growth Regulation
Volume8
Issue number6
StatePublished - 1 Dec 1989
Externally publishedYes

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