Farnesol and Candida albicans: Quorum Sensing or Not Quorum Sensing?

Bastiaan P. Krom; Niva Levy; Michael M. Meijler; Mary Ann Jabra-Rizk

doi:10.1002/ijch.201500025

Farnesol and Candida albicans: Quorum Sensing or Not Quorum Sensing?

Bastiaan P. Krom, Niva Levy, Michael M. Meijler, Mary Ann Jabra-Rizk

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Quorum sensing (QS) molecules function within communities of single-cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans.

Original language	English
Pages (from-to)	295-301
Number of pages	7
Journal	Israel Journal of Chemistry
Volume	56
Issue number	5
DOIs	https://doi.org/10.1002/ijch.201500025
State	Published - 1 May 2016

Keywords

Candida albicans
apoptosis
farnesol
metabolism
quorum sensing

ASJC Scopus subject areas

General Chemistry

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10.1002/ijch.201500025

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title = "Farnesol and Candida albicans: Quorum Sensing or Not Quorum Sensing?",

abstract = "Quorum sensing (QS) molecules function within communities of single-cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans.",

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AU - Jabra-Rizk, Mary Ann

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AB - Quorum sensing (QS) molecules function within communities of single-cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans.

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Farnesol and Candida albicans: Quorum Sensing or Not Quorum Sensing?

Abstract

Keywords

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