Fatal and near-fatal non-allergic reactions in patients with underlying cardiac disease receiving benzathine penicillin G in Israel and Switzerland

Matitiahu Berkovitch, Liat Ashkenazi-Hoffnung, Ilan Youngster, Dotan Shaniv, Dorit Dil-Nahlieli, Einat Gorelik, Martina Schäublin, Rudolf Stoller, Nour Karra, Eyal Schwartzberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Benzathine Penicillin G (BPG) is commonly used for treatment of penicillin-susceptible infections and secondary prevention of rheumatic fever. Death following administration of BPG is extremely rare-only a handful of cases have been described in the literature since the 1950's. In this case series from Israel and Switzerland, we describe nine cases of serious adverse reactions-six fatal reactions and three near-fatalities-occurring within minutes of receiving intramuscular BPG. Allergic reactions or faulty administration were not implicated in any of the cases; however, all patients had cardiac risk factors. This case series describes a relatively rare risk that should be borne in mind when prescribing BPG.

Original languageEnglish
Article number843
JournalFrontiers in Pharmacology
Volume8
Issue numberNOV
DOIs
StatePublished - 21 Nov 2017

Keywords

  • Adverse-events
  • Case-series
  • Death
  • Non-allergic
  • Penicillin

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