Fatal desquamative interstitial pneumonia in three infants siblings

Asher Tal, Esther Maor, Jacob Bar-Ziv, Rafael Gorodischer

    Research output: Contribution to journalArticlepeer-review

    50 Scopus citations


    Desquamative interstitial pneumonia occurred in three siblings. Cough, difficulty in breathing,cyanosis, and failure to gain weight appeared during the first month of life; progressive hypoxia followed, and the three infants died in respiratory failure before the age of 4 months despite intensive drug and supportive treatment. The radiographic and the histologic appearance of the pulmonary changes were similar in all three infants. Chest radiographs yielded normal findings initially, with rapid progression to a ground glass appearance of both lungs. Histologic findings of lung biopsies showed lymphoplasmocytic infiltration and fibrous thickening of the alveolar walls, swelling of alveolar lining cells, and large clumps of macrophages with PAS-positive foamy cytoplasm in the alveolar spaces.

    Original languageEnglish
    Pages (from-to)873-876
    Number of pages4
    JournalJournal of Pediatrics
    Issue number6
    StatePublished - 1 Jan 1984

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health


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