Fatty acid balance regulates α-synuclein pathology

Stav Cohen-Adiv; Avraham Ashkenazi

doi:10.1016/j.tins.2022.03.006

Fatty acid balance regulates α-synuclein pathology

Stav Cohen-Adiv, Avraham Ashkenazi

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

A recent study by Tripathi et al. used a protein engineering approach to demonstrate that cellular stress caused by familial α-synuclein mutations can be alleviated by altering the monounsaturated fatty acid equilibrium in neuronal cells. This work supports the notion that metabolic perturbation of lipids may be involved in the pathogenesis of Parkinson's disease.

Original language	English
Pages (from-to)	417-418
Number of pages	2
Journal	Trends in Neurosciences
Volume	45
Issue number	6
DOIs	https://doi.org/10.1016/j.tins.2022.03.006
State	Published - 1 Jun 2022
Externally published	Yes

Keywords

Parkinson's disease
aggregation-prone proteins
cellular membrane
monounsaturated fatty acid
α-synuclein

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.tins.2022.03.006

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title = "Fatty acid balance regulates α-synuclein pathology",

abstract = "A recent study by Tripathi et al. used a protein engineering approach to demonstrate that cellular stress caused by familial α-synuclein mutations can be alleviated by altering the monounsaturated fatty acid equilibrium in neuronal cells. This work supports the notion that metabolic perturbation of lipids may be involved in the pathogenesis of Parkinson's disease.",

keywords = "Parkinson's disease, aggregation-prone proteins, cellular membrane, monounsaturated fatty acid, α-synuclein",

author = "Stav Cohen-Adiv and Avraham Ashkenazi",

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AU - Ashkenazi, Avraham

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AB - A recent study by Tripathi et al. used a protein engineering approach to demonstrate that cellular stress caused by familial α-synuclein mutations can be alleviated by altering the monounsaturated fatty acid equilibrium in neuronal cells. This work supports the notion that metabolic perturbation of lipids may be involved in the pathogenesis of Parkinson's disease.

KW - Parkinson's disease

KW - aggregation-prone proteins

KW - cellular membrane

KW - monounsaturated fatty acid

KW - α-synuclein

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JO - Trends in Neurosciences

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ER -

Fatty acid balance regulates α-synuclein pathology

Abstract

Keywords

ASJC Scopus subject areas

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