Fear generalization in the primate amygdala

Jennifer Resnik; Rony Paz

doi:10.1038/nn.3900

Fear generalization in the primate amygdala

Jennifer Resnik, Rony Paz

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

Original language	English
Pages (from-to)	188-190
Journal	Nature Neuroscience
Volume	18
Issue number	2
DOIs	https://doi.org/10.1038/nn.3900
State	Published - 17 Feb 2015
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "Fear generalization in the primate amygdala",

abstract = "Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.",

author = "Jennifer Resnik and Rony Paz",

note = "Funding Information: We are grateful to H. Sompolinsky for discussions and suggestions. We thank Y. Shohat for major contribution to the work and welfare of the animals, E. Kahana and G. Hecht for help with medical and surgical procedures, E. Furman-Haran and N. Stern for magnetic resonance imaging procedures. This work was supported by the Minerva Foundation and the Israel Science Foundation (#26613 and ERC-FP7-StG #281171, R.P.).",

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N2 - Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

AB - Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

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Fear generalization in the primate amygdala

Abstract

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