Abstract
Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.
Original language | English |
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Pages (from-to) | 188-190 |
Journal | Nature Neuroscience |
Volume | 18 |
Issue number | 2 |
DOIs | |
State | Published - 17 Feb 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- General Neuroscience