Fear generalization in the primate amygdala

Jennifer Resnik; Rony Paz

doi:10.1038/nn.3900

Fear generalization in the primate amygdala

Jennifer Resnik
, Rony Paz

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

Original language	English
Pages (from-to)	188-190
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	2
DOIs	https://doi.org/10.1038/nn.3900
State	Published - 17 Feb 2015
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn.3900

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title = "Fear generalization in the primate amygdala",

abstract = "Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.",

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AB - Broad generalization of negative memories is a potential etiology for anxiety disorders, yet the underlying mechanisms remain unknown. We developed a non-human primate model that replicates behavioral observations in humans and identifies specific changes in tuning properties of amygdala neurons: the width of auditory tuning increases with the distance of its center from the conditioned stimulus. This center-width relationship can account for better detection and at the same time explain the wide stimulus generalization.

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DO - 10.1038/nn.3900

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JO - Nature Neuroscience

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Fear generalization in the primate amygdala

Abstract

ASJC Scopus subject areas

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