FeCl3/ultrasound mediated reaction of 2-aminothiophenol with aldehydes in water: Synthesis of 2-substituted benzothiazoles of pharmacological interest

Ponasanapalli Tirumala Venkata Ankayya Srinivas; Sallagundla Bhavani; Dandela Rambabu; Mandava Venkata Basaveswara Rao; Ravikumar Kapavarapu; Manojit Pal

doi:10.2174/1570180812666141216211045

FeCl₃/ultrasound mediated reaction of 2-aminothiophenol with aldehydes in water: Synthesis of 2-substituted benzothiazoles of pharmacological interest

Ponasanapalli Tirumala Venkata Ankayya Srinivas
, Sallagundla Bhavani
, Dandela Rambabu
, Mandava Venkata Basaveswara Rao
, Ravikumar Kapavarapu
, Manojit Pal

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We report a FeCl₃•6H₂O mediated green and rapid access to benzothiazole derivatives having a substituent at C-2 via the condensation of 2-aminothiophenol with various aldehydes under ultrasound irradiation and air. The reaction progressed well in water affording the expected products in good yields. Two of these compounds known to be potent anticancer agents showed good interactions with PDE4B in silico and inhibited this enzyme when tested in vitro.

Original language	English
Pages (from-to)	457-465
Number of pages	9
Journal	Letters in Drug Design and Discovery
Volume	12
Issue number	6
DOIs	https://doi.org/10.2174/1570180812666141216211045
State	Published - 1 Jan 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Benzothiazole
FeCl
PDE4
Ultrasound
Water

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

Access to Document

10.2174/1570180812666141216211045

Cite this

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title = "FeCl3/ultrasound mediated reaction of 2-aminothiophenol with aldehydes in water: Synthesis of 2-substituted benzothiazoles of pharmacological interest",

abstract = "We report a FeCl3•6H2O mediated green and rapid access to benzothiazole derivatives having a substituent at C-2 via the condensation of 2-aminothiophenol with various aldehydes under ultrasound irradiation and air. The reaction progressed well in water affording the expected products in good yields. Two of these compounds known to be potent anticancer agents showed good interactions with PDE4B in silico and inhibited this enzyme when tested in vitro.",

keywords = "Benzothiazole, FeCl, PDE4, Ultrasound, Water",

author = "Srinivas, \{Ponasanapalli Tirumala Venkata Ankayya\} and Sallagundla Bhavani and Dandela Rambabu and Rao, \{Mandava Venkata Basaveswara\} and Ravikumar Kapavarapu and Manojit Pal",

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FeCl₃/ultrasound mediated reaction of 2-aminothiophenol with aldehydes in water: Synthesis of 2-substituted benzothiazoles of pharmacological interest. / Srinivas, Ponasanapalli Tirumala Venkata Ankayya; Bhavani, Sallagundla; Rambabu, Dandela et al.
In: Letters in Drug Design and Discovery, Vol. 12, No. 6, 01.01.2015, p. 457-465.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - FeCl3/ultrasound mediated reaction of 2-aminothiophenol with aldehydes in water

T2 - Synthesis of 2-substituted benzothiazoles of pharmacological interest

AU - Srinivas, Ponasanapalli Tirumala Venkata Ankayya

AU - Bhavani, Sallagundla

AU - Rambabu, Dandela

AU - Rao, Mandava Venkata Basaveswara

AU - Kapavarapu, Ravikumar

AU - Pal, Manojit

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We report a FeCl3•6H2O mediated green and rapid access to benzothiazole derivatives having a substituent at C-2 via the condensation of 2-aminothiophenol with various aldehydes under ultrasound irradiation and air. The reaction progressed well in water affording the expected products in good yields. Two of these compounds known to be potent anticancer agents showed good interactions with PDE4B in silico and inhibited this enzyme when tested in vitro.

AB - We report a FeCl3•6H2O mediated green and rapid access to benzothiazole derivatives having a substituent at C-2 via the condensation of 2-aminothiophenol with various aldehydes under ultrasound irradiation and air. The reaction progressed well in water affording the expected products in good yields. Two of these compounds known to be potent anticancer agents showed good interactions with PDE4B in silico and inhibited this enzyme when tested in vitro.

KW - Benzothiazole

KW - FeCl

KW - PDE4

KW - Ultrasound

KW - Water

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EP - 465

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

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ER -