TY - JOUR
T1 - Feedback regulation of T cell development in the thymus
AU - Mehr, Ramit
AU - Perelson, Alan S.
AU - Fridkis-Hareli, Masha
AU - Globerson, Amiela
N1 - Funding Information:
We are much obliged to Prof[ Lee Segel for many helpful discussions[ Simulations were performed using {{GRIND|| software "Copyright R[ J[ De Boer\ 0872#[ This work was performed under the auspices of the U[S[ Department of Energy and supported by NIH grant AI17322\ the U[S[!Israel Binational Science Foundation Grant No[ 81!99060\ and the Santa Fe Institute through a Joseph P[ and Jeanne M[ Sullivan Foundation grant to their Theoretical Immunology program[
PY - 1996/7/21
Y1 - 1996/7/21
N2 - Recent findings suggest that mature T cells in the thymus may regulate the growth and differentiation of immature thymocytes. Here we use mathematical modeling and computer simulations to identify the thymocyte subsets that might serve as targets for regulation, and the processes that might be affected by regulation. Our results suggest that thymocyte development is subject to regulation through two feedback loops: mature CD4+ T cells exert a positive feedback on the single positive CD4+8- thymocyte compartment, by reducing CD4+8- cell death and possibly accelerating the differentiation of CD4+8+ thymocytes into CD4+8- thymocytes; they may also exert a negative feedback on the double-positive CD4+8+ thymocyte compartment, by reducing the proliferation or accelerating the maturation of these cells.
AB - Recent findings suggest that mature T cells in the thymus may regulate the growth and differentiation of immature thymocytes. Here we use mathematical modeling and computer simulations to identify the thymocyte subsets that might serve as targets for regulation, and the processes that might be affected by regulation. Our results suggest that thymocyte development is subject to regulation through two feedback loops: mature CD4+ T cells exert a positive feedback on the single positive CD4+8- thymocyte compartment, by reducing CD4+8- cell death and possibly accelerating the differentiation of CD4+8+ thymocytes into CD4+8- thymocytes; they may also exert a negative feedback on the double-positive CD4+8+ thymocyte compartment, by reducing the proliferation or accelerating the maturation of these cells.
UR - https://www.scopus.com/pages/publications/0030596613
U2 - 10.1006/jtbi.1996.0122
DO - 10.1006/jtbi.1996.0122
M3 - Article
AN - SCOPUS:0030596613
SN - 0022-5193
VL - 181
SP - 157
EP - 167
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 2
ER -