Feedforward-feedback multiple predictive controllers for glucose regulation in type 1 diabetes

Amjad Abu-Rmileh, Winston Garcia-Gabin

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Type 1 diabetic patients depend on insulin therapy to maintain blood glucose levels within safe range. The idea behind the " Artificial Pancreas" is to mimic, as close as possible, the functions of the natural pancreas in glucose sensing and insulin delivery, by using closed-loop control techniques. This work presents a model-based predictive control strategy for blood glucose regulation in diabetic patients. The controller is provided with a feedforward loop to improve meal compensation, a gain scheduling scheme to improve the controller performance in controlling the nonlinear glucose-insulin system, and an asymmetric cost function to reduce the hypoglycemic risk. Simulation scenarios with virtual patients are used to test the designed controller. The obtained results show a good controller performance in fasting conditions and meal disturbance rejection, and robustness against measurements errors, meal estimation errors, and changes in insulin sensitivity.

Original languageEnglish
Pages (from-to)113-123
Number of pages11
JournalComputer Methods and Programs in Biomedicine
Issue number1
StatePublished - 1 Jul 2010
Externally publishedYes


  • Artificial pancreas
  • Asymmetric cost function
  • Gain scheduling
  • Model predictive control
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics


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