Fertility and anogenital distance in women

Tamar Wainstock, Ilana Shoham-Vardi, Eyal Sheiner, Asnat Walfisch

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background Human and animal studies have found an association between prenatal androgen exposure and the anogenital distance (AGD). The aims of this study were to study the association between female AGD, reproductive health and background characteristics. Methods This was a cross sectional study, in which AGD were measured in 300 pregnant women who were recruited early during the first stage of labor. Demographic and health characteristics were collected and studied in association with AGD measurements. Results AGD presented with normal distribution (mean 40.3 mm ± 10.7) and was positively associated with maternal age (beta = 0.032, 95%CI 0.007–0.05, p = 0.01) and negatively associated with infertility treatments (beta = −1.06, 95%CI −1.99 to −0.12, p = 0.03). AGD was not associated with parity, ethnicity, height and other characteristics. Conclusions Adult females AGD is associated with age and fertility problems. Adult female AGD, used as a marker of early life exposure to EDCs, is possibly associated with reproductive characteristics.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalReproductive Toxicology
StatePublished - 1 Oct 2017


  • Anogenital distance
  • Early life exposures
  • Endocrine disrupting agents

ASJC Scopus subject areas

  • Toxicology


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