Fertility treatments-is it a risk factor for long-term maternal cardiovascular morbidity?

Revital R. Djaoui Ben Yakov, Roy Kessous, Ilana Shoham Vardi, Ruslan Sergienko, Eyal Sheiner

Research output: Contribution to journalMeeting Abstractpeer-review


To investigate whether patients who undergo fertility treatments (ovulation induction [OI] or in vitro fertilization [IVF]) have an increased risk for future maternal cardiovascular morbidity.
Study Design
A population-based study compared the incidence of long-term cardiovascular morbidity in a cohort of women with and without a previous exposure to fertility treatments. Deliveries occurred during a 25 years period, since the year 1988, with a mean follow-up duration of 11.2 years. Women with known cardiovascular disease and congenital cardiovascular malformations diagnosed prior to the index pregnancy, chronic hypertension and multiple pregnancies were excluded. Cardiovascular morbidity was divided into 4 categories according to severity and type including simple and complex cardiovascular events (e.g., angina pectoris and congestive heart failure, respectively), and invasive and noninvasive cardiac procedures (e.g., insertion of a stent and a treadmill stress test, respectively). Kaplan-Meier survival curve was used to estimate cumulative incidence of cardiovascular hospitalizations. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HR) for cardiovascular morbidity.

During the study period 99,291 patients met the inclusion criteria; 4.1% (n=4153) occurred in patients with exposure to fertility treatments. During the follow-up period, patients with exposure to fertility treatments (OI/IVF) did not have higher rates of cardiovascular morbidity (Table). Using a Kaplan-Meier survival curve, patients with an exposure to fertility treatments had no higher cumulative incidence of cardiovascular hospitalizations (Figure). Using a Cox proportional hazards model, adjusted for confounders such as preeclampsia, diabetes mellitus, and obesity, exposure to fertility treatments remained un-associated with cardiovascular hospitalizations (Adjusted HR=1.1; 95% CI 0.9-1.3; P=0.441).
Fertility treatments do not pose a significant risk for long-term maternal cardiovascular complications.
Original languageEnglish GB
Pages (from-to)S355-S355
Number of pages1
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
StatePublished - Jan 2016


Dive into the research topics of 'Fertility treatments-is it a risk factor for long-term maternal cardiovascular morbidity?'. Together they form a unique fingerprint.

Cite this