Fetal Brain Biometry: Is there an Agreement among Ultrasound, MRI and the Measurements at Birth?

Michal Gafner, Shalev Fried, Noa Gosher, Danielle Jeddah, Eliel Kedar Sade, Eran Barzilay, Arnaldo Mayer, Eldad Katorza

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations


    Purpose: Measurement of the fetal brain can be achieved by different modalities, we aimed to assess the agreement between these methods and the head circumference at birth. Methods: A retrospective study conducted between 2011-2018 at a tertiary referral medical center. Sonographic head circumference (HC), 2D MRI bi-parietal diameter (BPD) and occipito-frontal diameter (OFD), 3D MRI supra-tentorial volume (STV), and head circumference (HC) at birth were measured and converted into centiles according to gestational age. Spearman's rank correlation coefficient was used to assess the correlation between the modalities. Results: A total of 88 fetuses were included. Mean gestational age at the time of fetal US and brain MRI acquisition were 34.4 ± 2.8 and 34.6 ± 2.6 weeks, respectively. A correlation was found between prenatal sonographic HC and the 3D MRI STV centiles (Rs = 0.859, p < 0.001), the BPD in 2D MRI (Rs = 0.813, p < 0.001), and the OFD in 2D MRI (Rs = 0.840, p < 0.001). Sonographic HC, OFD on 2D MRI, and STV on 3D MRI were all found to be correlated with the HC at birth (Rs = 0.865, p < 0.001; Rs 0.816, p < 0.001; Rs = 0.825, p < 0.001, respectively). Conclusions: There is a statistically significant agreement among the different prenatal clinically used modalities for measuring fetal brain and the head circumference at birth, however, this correlation is not perfect. Further study is needed to investigate the long-term prognosis of these fetuses.

    Original languageEnglish
    Article number109369
    JournalEuropean Journal of Radiology
    StatePublished - 1 Dec 2020


    • Biometry
    • Central nervous system
    • Fetus
    • Magnetic resonance imaging
    • Ultrasound

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging


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