Fetal Exposure to Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Spontaneous Abortions

Sharon Daniel, Gideon Koren, Eitan Lunenfeld, Natalya Bilenko, Ronit Ratzon, Amalia Levy

Research output: Contribution to journalMeeting Abstractpeer-review


Background: Spontaneous abortions are the most com-mon complication of pregnancy. Non-steroidal anti-inflam-matory drugs (NSAIDs) are widely used during pregnancy.Published data are inconsistent regarding the risk forspontaneous abortions following exposure to NSAIDs.Methods: A historical cohort study was conductedincluding all women who conceived between January 2003and December 2009 and admitted for birth or spontane-ous abortion at Soroka Medical Center, Clalit Health Serv-ices, Israel. A computerized database of medicationdispensation was linked with two computerized databasescontaining information on births and spontaneous abor-tions. Time-varying COX regression models were con-structed adjusting for mother’s age, diabetes mellitus,hypothyroidism, obesity, hypercoagulable or inflammatoryconditions, recurrent miscarriages, intrauterine contracep-tive device, ethnicity, tobacco use, and the year ofadmission.Results: Study participants included 65,457 womenwho conceived during the study pe riod: 58,949 (90.1%)for birth and 6,508 (9.9%) for spontaneous abortion. Atotal of 4,495 (6.9 %) pregnant women were exposed toNSAIDs during the study period. Exposure to NSAIDs wasnot an independent risk factor for spontaneous abortionfor NSAID groups (adjusted hazard ratio [aHR], 1.10; 95%confidence interval [CI], 0.99–1.22; and aHR, 1.43; 95% CI,0.79–2.59 for non-selective and selective COX2 inhibitors,respectively) or for specific NSAID drugs, except for a sig-nificant aHR of 2.8 (95% CI, 1.70–4.69) for indomethacin.Additionally, no dose–response effect was found.Conclusion: No increased risk for spontaneous abor-tions was found following exposure to NSAIDs. Furtherresearch is needed to assess the risk following exposureto selective COX2 inhibitors
Original languageEnglish GB
Pages (from-to)526-526
Number of pages41
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Issue number7
StatePublished - 7 Jul 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Developmental Biology


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