Fetal wide subarachnoid space and its outcome in cases of macrocephaly without ventriculomegaly

Joel Baron, Salvatore Andrea Mastrolia, Ilan Shelef, Dan Tirosh, Analia Mijalovsky, Yigal Ben-Harush, Reli Hershkovitz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To examine the occurrence and outcomes of fetuses with wide subarachnoid space (WSS) without ventriculomegaly in pregnant women with fetal macrocephaly as a sole diagnosis. Study design: A retrospective study was performed, analyzing patients with fetal macrocephaly between the years 2008 and 2018. All these patients underwent MRI, in order to detect brain anomalies. In the absence of any other brain abnormality, they were evaluated for WSS and their offspring’s database was followed for at least two years after birth. Results: Ten patients were found to be carrying fetuses with macrocephaly, nine of them were diagnosed with WSS without ventriculomegaly prior to delivery. Following at least two years of follow up, all patients did not present significant neurodevelopmental abnormalities, apart from one child that had a genetic mutation of 15q21.2-22.31 deletion with other anomalies that were not diagnosed prenatally. Conclusions: We present herein for the first time in the literature a cohort of patients with a prenatal diagnosis of WSS without ventriculomegaly in fetuses with macrocephaly. Our data show that, in the presence of normal anomaly scan and normal chromosomal study, there is a low chance for significant neurodevelopmental abnormalities in fetuses with WSS without ventriculomegaly.

Original languageEnglish
Pages (from-to)2570-2575
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number15
StatePublished - 2 Aug 2020


  • Fetal MRI
  • macrocephaly
  • neurodevelopmental delay
  • pregnancy
  • wide subarachnoid space

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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