FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Minh Binh Nguyen; Idan Cohen; Vinod Kumar; Zijian Xu; Carmit Bar; Katherine L. Dauber-Decker; Pai Chi Tsai; Pauline Marangoni; Ophir D. Klein; Ya Chieh Hsu; Ting Chen; Marja L. Mikkola; Elena Ezhkova

doi:10.1038/s41467-018-04399-y

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L. Dauber-Decker, Pai Chi Tsai, Pauline Marangoni, Ophir D. Klein, Ya Chieh Hsu, Ting Chen, Marja L. Mikkola, Elena Ezhkova

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells. Interestingly, while SOX9 is critical for HFSC specification, it is dispensable for Merkel cell formation. Conversely, FGFR2 is required for Merkel cell formation but is dispensable for HFSCs. Together, our studies uncover SOX9(+) cells as precursors of Merkel cells and show the requirement for FGFR2-mediated epithelial signalling in Merkel cell specification.

Original language	English
Article number	2333
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-04399-y
State	Published - 1 Dec 2018
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Nguyen, M. B., Cohen, I., Kumar, V., Xu, Z., Bar, C., Dauber-Decker, K. L., Tsai, P. C., Marangoni, P., Klein, O. D., Hsu, Y. C., Chen, T., Mikkola, M. L., & Ezhkova, E. (2018). FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nature Communications, 9(1), Article 2333. https://doi.org/10.1038/s41467-018-04399-y

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title = "FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells",

abstract = "Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells. Interestingly, while SOX9 is critical for HFSC specification, it is dispensable for Merkel cell formation. Conversely, FGFR2 is required for Merkel cell formation but is dispensable for HFSCs. Together, our studies uncover SOX9(+) cells as precursors of Merkel cells and show the requirement for FGFR2-mediated epithelial signalling in Merkel cell specification.",

author = "Nguyen, {Minh Binh} and Idan Cohen and Vinod Kumar and Zijian Xu and Carmit Bar and Dauber-Decker, {Katherine L.} and Tsai, {Pai Chi} and Pauline Marangoni and Klein, {Ophir D.} and Hsu, {Ya Chieh} and Ting Chen and Mikkola, {Marja L.} and Elena Ezhkova",

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AU - Nguyen, Minh Binh

AU - Cohen, Idan

AU - Kumar, Vinod

AU - Xu, Zijian

AU - Bar, Carmit

AU - Dauber-Decker, Katherine L.

AU - Tsai, Pai Chi

AU - Marangoni, Pauline

AU - Klein, Ophir D.

AU - Hsu, Ya Chieh

AU - Chen, Ting

AU - Mikkola, Marja L.

AU - Ezhkova, Elena

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells. Interestingly, while SOX9 is critical for HFSC specification, it is dispensable for Merkel cell formation. Conversely, FGFR2 is required for Merkel cell formation but is dispensable for HFSCs. Together, our studies uncover SOX9(+) cells as precursors of Merkel cells and show the requirement for FGFR2-mediated epithelial signalling in Merkel cell specification.

AB - Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells. Interestingly, while SOX9 is critical for HFSC specification, it is dispensable for Merkel cell formation. Conversely, FGFR2 is required for Merkel cell formation but is dispensable for HFSCs. Together, our studies uncover SOX9(+) cells as precursors of Merkel cells and show the requirement for FGFR2-mediated epithelial signalling in Merkel cell specification.

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FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

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