Fibromyalgia and Gaucher's disease

A. Brautbar, D. Elstein, B. Pines, N. Krienen, J. Hemmer, D. Buskila, A. Zimran

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Patients with symptomatic Gaucher's disease sometimes have non-specific symptoms (such as general malaise with widespread musculoskeletal pains) that respond poorly to enzyme replacement treatment. These may indicate fibromyalgia syndrome; if so, other therapeutic options might be more appropriate. Aim: To identify patients with Gaucher's disease for whom fibromyalgia-specific therapy may be therapeutic. Design: Questionnaire-based survey. Methods: Adult patients (n = 109) with non-neuronopathic Gaucher's disease and adult healthy controls (n = 108) completed health-related questionnaires including the Fibromyalgia Impact Questionnaire, and underwent testing with a dolorimeter to ascertain sensitivity at 22 tender points. Results: Six patients, but no controls, met the criteria for fibromyalgia. Patients with fibromyalgia had a significantly greater incidence of co-morbidities (p = 0.014) relative to other patients with Gaucher's disease; four suffered from bone involvement and were receiving enzyme therapy, but two were untreated. Discussion: The presence of fibromyalgia-specific trigger points may result from multiple aetiologies, or may be an independently-sorting predisposition. Our findings cannot distinguish between these possibilities, but if fibromyalgia were the cause, enzyme replacement therapy would be expensive and inappropriate.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalQJM - Monthly Journal of the Association of Physicians
Volume99
Issue number2
DOIs
StatePublished - 1 Feb 2006
Externally publishedYes

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