TY - JOUR
T1 - Fibromyalgia and mortality
T2 - a systematic review and meta-analysis
AU - Treister-Goltzman, Yulia
AU - Peleg, Roni
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023/7/10
Y1 - 2023/7/10
N2 - Objective To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis. Methods The authors searched the PubMed, Scopus, and Web of Science databases using the key words € fibromyalgia' and € mortality' to identify studies that addressed an association between fibromyalgia and mortality. Original papers that assessed associations between fibromyalgia and mortality (all or specific causes) and provided an effect measure (hazard ratio (HR), standardised mortality ratio (SMR), odds ratio (OR)) quantifying the relationship between fibromyalgia and mortality were included in the systematic review. Of 557 papers that were initially identified using the search words, 8 papers were considered eligible for the systematic review and meta-analysis. We used a Newcastle-Ottawa scale to assess the risk of bias in the studies. Results The total fibromyalgia group included 188 751 patients. An increased HR was found for all-cause mortality (HR 1.27, 95% CI 1.04 to 1.51), but not for the subgroup diagnosed by the 1990 criteria. There was a borderline increased SMR for accidents (SMR 1.95, 95% CI 0.97 to 3.92), an increased risk for mortality from infections (SMR 1.66, 95% CI 1.15 to 2.38), and suicide (SMR 3.37, 95% CI 1.52 to 7.50), and a decreased mortality rate for cancer (SMR 0.82, 95% CI 0.69 to 0.97). The studies showed significant heterogeneity. Conclusions These potential associations indicate that fibromyalgia should be taken seriously, with a special focus on screening for suicidal ideation, accident prevention, and the prevention and treatment of infections.
AB - Objective To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis. Methods The authors searched the PubMed, Scopus, and Web of Science databases using the key words € fibromyalgia' and € mortality' to identify studies that addressed an association between fibromyalgia and mortality. Original papers that assessed associations between fibromyalgia and mortality (all or specific causes) and provided an effect measure (hazard ratio (HR), standardised mortality ratio (SMR), odds ratio (OR)) quantifying the relationship between fibromyalgia and mortality were included in the systematic review. Of 557 papers that were initially identified using the search words, 8 papers were considered eligible for the systematic review and meta-analysis. We used a Newcastle-Ottawa scale to assess the risk of bias in the studies. Results The total fibromyalgia group included 188 751 patients. An increased HR was found for all-cause mortality (HR 1.27, 95% CI 1.04 to 1.51), but not for the subgroup diagnosed by the 1990 criteria. There was a borderline increased SMR for accidents (SMR 1.95, 95% CI 0.97 to 3.92), an increased risk for mortality from infections (SMR 1.66, 95% CI 1.15 to 2.38), and suicide (SMR 3.37, 95% CI 1.52 to 7.50), and a decreased mortality rate for cancer (SMR 0.82, 95% CI 0.69 to 0.97). The studies showed significant heterogeneity. Conclusions These potential associations indicate that fibromyalgia should be taken seriously, with a special focus on screening for suicidal ideation, accident prevention, and the prevention and treatment of infections.
KW - Fibromyalgia
KW - Infections
KW - Outcome Assessment, Health Care
UR - http://www.scopus.com/inward/record.url?scp=85164293494&partnerID=8YFLogxK
U2 - 10.1136/rmdopen-2023-003005
DO - 10.1136/rmdopen-2023-003005
M3 - Article
C2 - 37429737
AN - SCOPUS:85164293494
SN - 2056-5933
VL - 9
JO - RMD Open
JF - RMD Open
IS - 3
M1 - e003005
ER -