Flat Oral Glucose Tolerance Test during Pregnancy: Maternal Characteristics and Risk for Adverse Outcomes

Amir Naeh; Renana Wilkof-Segev; Anat Jaffe; Esther Maor-Sagie; Mordechai Hallak; Rinat Gabbay-Benziv

doi:10.2337/cd20-0099

Flat Oral Glucose Tolerance Test during Pregnancy: Maternal Characteristics and Risk for Adverse Outcomes

Amir Naeh, Renana Wilkof-Segev, Anat Jaffe, Esther Maor-Sagie, Mordechai Hallak, Rinat Gabbay-Benziv

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Flat oral glucose tolerance test (OGTT) curve is characterized by low glucose levels, seemingly nonresponsive to glucose load. Few studies have explored flat OGTT during pregnancy and have yielded conflicting results, some suggesting risk for fetal growth restriction. This study evaluated the characteristics and perinatal outcomes of women with a flat OGTT during pregnancy. We found that a flat OGTT curve occurs in younger, leaner pregnant women. Also, flat OGTT curve was significantly associated with a male fetus and higher levels of pregnancy-associated plasma protein A at the first-trimester screening. Although flat OGTT can possibly reflect some degree of hyperinsulinemia, it is generally not associated with adverse maternal or neonatal outcomes.

Original language	English
Pages (from-to)	313-319
Number of pages	7
Journal	Clinical Diabetes
Volume	39
Issue number	3
DOIs	https://doi.org/10.2337/cd20-0099
State	Published - 1 Jun 2021
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/cd20-0099

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title = "Flat Oral Glucose Tolerance Test during Pregnancy: Maternal Characteristics and Risk for Adverse Outcomes",

abstract = "Flat oral glucose tolerance test (OGTT) curve is characterized by low glucose levels, seemingly nonresponsive to glucose load. Few studies have explored flat OGTT during pregnancy and have yielded conflicting results, some suggesting risk for fetal growth restriction. This study evaluated the characteristics and perinatal outcomes of women with a flat OGTT during pregnancy. We found that a flat OGTT curve occurs in younger, leaner pregnant women. Also, flat OGTT curve was significantly associated with a male fetus and higher levels of pregnancy-associated plasma protein A at the first-trimester screening. Although flat OGTT can possibly reflect some degree of hyperinsulinemia, it is generally not associated with adverse maternal or neonatal outcomes.",

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AU - Jaffe, Anat

AU - Maor-Sagie, Esther

AU - Hallak, Mordechai

AU - Gabbay-Benziv, Rinat

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Flat Oral Glucose Tolerance Test during Pregnancy: Maternal Characteristics and Risk for Adverse Outcomes

Abstract

ASJC Scopus subject areas

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