Flow velocity analysis of umbilical and uterine artery flow in pre‐eclampsia treated with propranolol or pindolol

Israel Meizner, Esther Paran, Miriam Katz, Gershon Holcberg, Vaclav Insler

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13 Scopus citations

Abstract

In a double blind study, 20 gravidas with pre‐eclampsia were randomly allocated to treatment with either propranolol 120 mg/day or pindolol 15 mg/day for 7 days. Flow velocimetry was performed before and after treatment to assess the influence of these two regimens of beta blocker on the feto‐placental circulation. A continuous wave Doppler unit was used to measure umbilical and uterine artery flow velocity waveforms. The systolic/diastolic (A/B) ratio and the systolic minus diastolic divided by systolic (A‐B)/A ratio (resistance index) were used as indexes of blood flow resistance in the umbilical and uterine arteries, respectively. A resistance to flow in the uteroplacental circulation was significantly less in patients treated with pindolol compared to those treated with propranolol (P < 0.01). The same pattern was also found in umbilical velocimetry, although the statistical significance was borderline (P = 0.06). Although both drugs were equally effective in reducing blood pressure at rest, their effect on the peripheral resistance was different. Pindolol appears to act in part through a peripheral vascular mechanism. Our data support this assumption because the flow in the uteroplacental bed, as reflected by a decrease in resistance index, improved when patients were treated with the drug pindolol.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalJournal of Clinical Ultrasound
Volume20
Issue number2
DOIs
StatePublished - 1 Jan 1992

Keywords

  • Blood flow
  • Preeclampsia
  • Pregnancy‐induced hypertension
  • Umbilical flow
  • Uterine flow

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