Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

Shimon Ben-Shabat; Craig A. Parish; Masaru Hashimoto; Jianghua Liu; Koji Nakanishi; Janet R. Sparrow

doi:10.1016/S0960-894X(01)00314-6

Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

Shimon Ben-Shabat, Craig A. Parish, Masaru Hashimoto, Jianghua Liu, Koji Nakanishi, Janet R. Sparrow

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.

Original language	English
Pages (from-to)	1533-1540
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(01)00314-6
State	Published - 18 Jun 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration",

abstract = "The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.",

author = "Shimon Ben-Shabat and Parish, {Craig A.} and Masaru Hashimoto and Jianghua Liu and Koji Nakanishi and Sparrow, {Janet R.}",

note = "Funding Information: Experiments performed in the authors' laboratories were supported by National Institutes of Health grants GM-36564 (K.N.) and EY-12951 (J.R.S.), and unrestricted funds from Research to Prevent Blindness (J.R.S.). ",

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AU - Ben-Shabat, Shimon

AU - Parish, Craig A.

AU - Hashimoto, Masaru

AU - Liu, Jianghua

AU - Nakanishi, Koji

AU - Sparrow, Janet R.

N1 - Funding Information: Experiments performed in the authors' laboratories were supported by National Institutes of Health grants GM-36564 (K.N.) and EY-12951 (J.R.S.), and unrestricted funds from Research to Prevent Blindness (J.R.S.).

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AB - The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.

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Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

Abstract

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