Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration

Shimon Ben-Shabat, Craig A. Parish, Masaru Hashimoto, Jianghua Liu, Koji Nakanishi, Janet R. Sparrow

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.

Original languageEnglish
Pages (from-to)1533-1540
Number of pages8
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number12
DOIs
StatePublished - 18 Jun 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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