Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil

M. K.Chaitanya Mannava; Manish K. Bommaka; Rambabu Dandela; K. Anand Solomon; Ashwini K. Nangia

doi:10.1039/d1cc07187d

Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil

M. K.Chaitanya Mannava, Manish K. Bommaka, Rambabu Dandela, K. Anand Solomon, Ashwini K. Nangia

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

Original language	English
Pages (from-to)	5822-5880
Number of pages	59
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/d1cc07187d
State	Accepted/In press - 1 Jan 2022
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d1cc07187d

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title = "Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil",

abstract = "Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.",

author = "Mannava, \{M. K.Chaitanya\} and Bommaka, \{Manish K.\} and Rambabu Dandela and Solomon, \{K. Anand\} and Nangia, \{Ashwini K.\}",

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doi = "10.1039/d1cc07187d",

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T1 - Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil

AU - Mannava, M. K.Chaitanya

AU - Bommaka, Manish K.

AU - Dandela, Rambabu

AU - Solomon, K. Anand

AU - Nangia, Ashwini K.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

AB - Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

UR - https://www.scopus.com/pages/publications/85128261351

U2 - 10.1039/d1cc07187d

DO - 10.1039/d1cc07187d

M3 - Article

C2 - 35393986

AN - SCOPUS:85128261351

SN - 1359-7345

SP - 5822

EP - 5880

JO - Chemical Communications

JF - Chemical Communications

ER -

Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil

Abstract

ASJC Scopus subject areas

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