Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil

M. K.Chaitanya Mannava; Manish K. Bommaka; Rambabu Dandela; K. Anand Solomon; Ashwini K. Nangia

doi:10.1039/d1cc07187d

Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil

M. K.Chaitanya Mannava
, Manish K. Bommaka
, Rambabu Dandela
, K. Anand Solomon
, Ashwini K. Nangia

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

Original language	English
Pages (from-to)	5582-5585
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	37
DOIs	https://doi.org/10.1039/d1cc07187d
State	Published - 7 May 2022
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d1cc07187d

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title = "Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil",

abstract = "Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.",

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AU - Mannava, M. K.Chaitanya

AU - Bommaka, Manish K.

AU - Dandela, Rambabu

AU - Solomon, K. Anand

AU - Nangia, Ashwini K.

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry, 2022

PY - 2022/5/7

Y1 - 2022/5/7

N2 - Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

AB - Crystalline salts of the low solubility and low permeability drug naftopidil were investigated with mono-, di-, tri-, and tetrafluorobenzoic acids as coformers to show that 245TFBA (2,4,5-trifluorobenzoic acid) is the optimal salt with faster dissolution and high permeability, thereby opening the study of fluorinated coformers in pharmaceutical cocrystals and salts.

UR - https://www.scopus.com/pages/publications/85128261351

U2 - 10.1039/d1cc07187d

DO - 10.1039/d1cc07187d

M3 - Article

C2 - 35393986

AN - SCOPUS:85128261351

SN - 1359-7345

VL - 58

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EP - 5585

JO - Chemical Communications

JF - Chemical Communications

IS - 37

ER -

Fluorobenzoic acid coformers to improve the solubility and permeability of the BCS class IV drug naftopidil

Abstract

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