Focal Controlled Drug Delivery: Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract

Omri Wolk, Arik Dahan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The intestinal tract is a long and complex organ, with significantly variable characteristics throughout it. It is broadly divided to several segments: the small intestine, which is subdivided to duodenum, jejunum, and ileum, and the colon. Each segment has its own unique environment. Conditions in each segment are dependent on a multitude of factors. This chapter surveys three such factors: environmental pH values, transporter expression levels, and CYP3A4 expression. Their influence on drug absorption is discussed, and technologies to exploit them for optimization of absorption are reviewed. In conclusion, segment-specific drug absorption and delivery is a highly important research field; a thorough understanding of the determinants of intestinal environment, considering the whole of the human intestine, is crucial for successful targeting of drugs to specific intestinal regions and exploitation of the variable intestinal conditions for better drug delivery and therapeutic effect.
Original languageEnglish
Title of host publicationFocal Controlled Drug Delivery
Pages343-357
Number of pages15
DOIs
StatePublished - 1 Jan 2014

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