Folate and biotin based bifunctional quantum dots as fluorescent cell labels

Atanu Chakraborty, Amit Ranjan Maity, Nikhil R. Jana

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Although nanoprobes functionalized with one type of affinity molecule are commonly used as bioimaging probes, biolabeling studies of nanoprobes functionalized with more than one type of affinity molecule remains an unexplored area of research. Here we show that the labeling specificity of a nanoprobe can be enhanced if they are functionalized with more than one type of affinity molecule. We have synthesized functional quantum dots (QDs) of 20-30 nm hydrodynamic diameter having both folate and biotin on their surface. This dual functional nanoprobe has an enhanced labeling specificity to cancer cells/tissue as compared to folate or biotin based monofunctional QDs.

Original languageEnglish
Pages (from-to)10434-10438
Number of pages5
JournalRSC Advances
Volume4
Issue number21
DOIs
StatePublished - 28 Feb 2014
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry (all)
  • Chemical Engineering (all)

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